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Efficacy of an EGFR-specific peptide against EGFR-dependent cancer cell lines and tumor xenografts.
Ahsan A, Ramanand SG, Bergin IL, Zhao L, Whitehead CE, Rehemtulla A, Ray D, Pratt WB, Lawrence TS, Nyati MK. Ahsan A, et al. Neoplasia. 2014 Feb;16(2):105-14. doi: 10.1593/neo.14182. Neoplasia. 2014. PMID: 24709418 Free PMC article.
The effect is specific for EGFR versus other Hsp90 client proteins [Ahsan et al.: (2013). Destabilization of the epidermal growth factor receptor (EGFR) by a peptide that inhibits EGFR binding to heat shock protein 90 and receptor dimerization. J Biol Chem288, 26879 …
The effect is specific for EGFR versus other Hsp90 client proteins [Ahsan et al.: (2013). Destabilization of the epidermal growth fac …
KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.
Shukla S, Allam US, Ahsan A, Chen G, Krishnamurthy PM, Marsh K, Rumschlag M, Shankar S, Whitehead C, Schipper M, Basrur V, Southworth DR, Chinnaiyan AM, Rehemtulla A, Beer DG, Lawrence TS, Nyati MK, Ray D. Shukla S, et al. Among authors: ahsan a. Neoplasia. 2014 Feb;16(2):115-28. doi: 10.1593/neo.14184. Neoplasia. 2014. PMID: 24709419 Free PMC article.
362 results