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Metformin improves healthspan and lifespan in mice.
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R. Martin-Montalvo A, et al. Among authors: de cabo r. Nat Commun. 2013;4:2192. doi: 10.1038/ncomms3192. Nat Commun. 2013. PMID: 23900241 Free PMC article.
Binding of manumycin A inhibits IkappaB kinase beta activity.
Bernier M, Kwon YK, Pandey SK, Zhu TN, Zhao RJ, Maciuk A, He HJ, Decabo R, Kole S. Bernier M, et al. J Biol Chem. 2006 Feb 3;281(5):2551-61. doi: 10.1074/jbc.M511878200. Epub 2005 Nov 30. J Biol Chem. 2006. PMID: 16319058 Free article.
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency.
López-Lluch G, Hunt N, Jones B, Zhu M, Jamieson H, Hilmer S, Cascajo MV, Allard J, Ingram DK, Navas P, de Cabo R. López-Lluch G, et al. Among authors: de cabo r. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1768-73. doi: 10.1073/pnas.0510452103. Epub 2006 Jan 30. Proc Natl Acad Sci U S A. 2006. PMID: 16446459 Free PMC article.
367 results