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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23.
Arch Toxicol. 2013.
PMID: 23974980
Free PMC article.
Review.
Development of an in vitro liver toxicity prediction model based on longer term primary rat hepatocyte culture.
Hrach J, Mueller SO, Hewitt P.
Hrach J, et al.
Toxicol Lett. 2011 Oct 10;206(2):189-96. doi: 10.1016/j.toxlet.2011.07.012. Epub 2011 Jul 23.
Toxicol Lett. 2011.
PMID: 21807079
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Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug-drug interaction studies.
Tuschl G, Hrach J, Walter Y, Hewitt PG, Mueller SO.
Tuschl G, et al. Among authors: hrach j.
Chem Biol Interact. 2009 Sep 14;181(1):124-37. doi: 10.1016/j.cbi.2009.05.015. Epub 2009 May 29.
Chem Biol Interact. 2009.
PMID: 19482013
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