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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23.
Arch Toxicol. 2013.
PMID: 23974980
Free PMC article.
Review.
Genome-wide comparison between IL-17 and combined TNF-alpha/IL-17 induced genes in primary murine hepatocytes.
Sparna T, Rétey J, Schmich K, Albrecht U, Naumann K, Gretz N, Fischer HP, Bode JG, Merfort I.
Sparna T, et al. Among authors: schmich k.
BMC Genomics. 2010 Apr 7;11:226. doi: 10.1186/1471-2164-11-226.
BMC Genomics. 2010.
PMID: 20374638
Free PMC article.
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Modeling the TNFα-induced apoptosis pathway in hepatocytes.
Schlatter R, Schmich K, Lutz A, Trefzger J, Sawodny O, Ederer M, Merfort I.
Schlatter R, et al. Among authors: schmich k.
PLoS One. 2011 Apr 20;6(4):e18646. doi: 10.1371/journal.pone.0018646.
PLoS One. 2011.
PMID: 21533085
Free PMC article.
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Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner.
Schmich K, Schlatter R, Corazza N, Sá Ferreira K, Ederer M, Brunner T, Borner C, Merfort I.
Schmich K, et al.
Hepatology. 2011 Jan;53(1):282-92. doi: 10.1002/hep.23987. Epub 2010 Sep 24.
Hepatology. 2011.
PMID: 20872776
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Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes.
Walter D, Schmich K, Vogel S, Pick R, Kaufmann T, Hochmuth FC, Haber A, Neubert K, McNelly S, von Weizsäcker F, Merfort I, Maurer U, Strasser A, Borner C.
Walter D, et al. Among authors: schmich k.
Hepatology. 2008 Dec;48(6):1942-53. doi: 10.1002/hep.22541.
Hepatology. 2008.
PMID: 19003879
Free PMC article.
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ON/OFF and beyond--a boolean model of apoptosis.
Schlatter R, Schmich K, Avalos Vizcarra I, Scheurich P, Sauter T, Borner C, Ederer M, Merfort I, Sawodny O.
Schlatter R, et al. Among authors: schmich k.
PLoS Comput Biol. 2009 Dec;5(12):e1000595. doi: 10.1371/journal.pcbi.1000595. Epub 2009 Dec 11.
PLoS Comput Biol. 2009.
PMID: 20011108
Free PMC article.
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Noxa/Mcl-1 balance influences the effect of the proteasome inhibitor MG-132 in combination with anticancer agents in pancreatic cancer cell lines.
Naumann K, Schmich K, Jaeger C, Kratz F, Merfort I.
Naumann K, et al. Among authors: schmich k.
Anticancer Drugs. 2012 Jul;23(6):614-26. doi: 10.1097/CAD.0b013e3283504e53.
Anticancer Drugs. 2012.
PMID: 22314265
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Structure and cytotoxicity of arnamial and related fungal sesquiterpene aryl esters.
Misiek M, Williams J, Schmich K, Hüttel W, Merfort I, Salomon CE, Aldrich CC, Hoffmeister D.
Misiek M, et al. Among authors: schmich k.
J Nat Prod. 2009 Oct;72(10):1888-91. doi: 10.1021/np900314p.
J Nat Prod. 2009.
PMID: 19795841
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