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Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: a new approach with future therapeutic potential.
Boros G, Miko E, Muramatsu H, Weissman D, Emri E, Rózsa D, Nagy G, Juhász A, Juhász I, van der Horst G, Horkay I, Remenyik É, Karikó K, Emri G. Boros G, et al. Among authors: van der horst g. J Photochem Photobiol B. 2013 Dec 5;129:93-9. doi: 10.1016/j.jphotobiol.2013.09.010. Epub 2013 Oct 11. J Photochem Photobiol B. 2013. PMID: 24211294 Free PMC article.
Identification of Cyclobutane Pyrimidine Dimer-Responsive Genes Using UVB-Irradiated Human Keratinocytes Transfected with In Vitro-Synthesized Photolyase mRNA.
Boros G, Miko E, Muramatsu H, Weissman D, Emri E, van der Horst GT, Szegedi A, Horkay I, Emri G, Karikó K, Remenyik É. Boros G, et al. Among authors: van der horst gt. PLoS One. 2015 Jun 29;10(6):e0131141. doi: 10.1371/journal.pone.0131141. eCollection 2015. PLoS One. 2015. PMID: 26121660 Free PMC article.
Powerful skin cancer protection by a CPD-photolyase transgene.
Jans J, Schul W, Sert YG, Rijksen Y, Rebel H, Eker AP, Nakajima S, van Steeg H, de Gruijl FR, Yasui A, Hoeijmakers JH, van der Horst GT. Jans J, et al. Curr Biol. 2005 Jan 26;15(2):105-15. doi: 10.1016/j.cub.2005.01.001. Curr Biol. 2005. PMID: 15668165 Free article.
The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes.
Brash DE, Wikonkal NM, Remenyik E, van der Horst GT, Friedberg EC, Cheo DL, van Steeg H, Westerman A, van Kranen HJ. Brash DE, et al. Among authors: van der horst gt, van kranen hj, van steeg h. J Invest Dermatol. 2001 Nov;117(5):1234-40. doi: 10.1046/j.0022-202x.2001.01554.x. J Invest Dermatol. 2001. PMID: 11710938 Free article.
Photorepair of Either CPD or 6-4PP DNA Lesions in Basal Keratinocytes Attenuates Ultraviolet-Induced Skin Effects in Nucleotide Excision Repair Deficient Mice.
Kajitani GS, Quayle C, Garcia CCM, Fotoran WL, Dos Santos JFR, van der Horst GTJ, Hoeijmakers JHJ, Menck CFM. Kajitani GS, et al. Among authors: van der horst gtj. Front Immunol. 2022 Mar 29;13:800606. doi: 10.3389/fimmu.2022.800606. eCollection 2022. Front Immunol. 2022. PMID: 35422806 Free PMC article.
Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer.
Jans J, Garinis GA, Schul W, van Oudenaren A, Moorhouse M, Smid M, Sert YG, van der Velde A, Rijksen Y, de Gruijl FR, van der Spek PJ, Yasui A, Hoeijmakers JH, Leenen PJ, van der Horst GT. Jans J, et al. Mol Cell Biol. 2006 Nov;26(22):8515-26. doi: 10.1128/MCB.00807-06. Epub 2006 Sep 11. Mol Cell Biol. 2006. PMID: 16966369 Free PMC article.
321 results