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Structure of a eukaryotic thiaminase I.
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):137-42. doi: 10.1073/pnas.1315882110. Epub 2013 Dec 18.
Proc Natl Acad Sci U S A. 2014.
PMID: 24351929
Free PMC article.
Inhibition of thiamin diphosphate dependent enzymes by 3-deazathiamin diphosphate.
Mann S, Perez Melero C, Hawksley D, Leeper FJ.
Mann S, et al. Among authors: hawksley d.
Org Biomol Chem. 2004 Jun 21;2(12):1732-41. doi: 10.1039/b403619k. Epub 2004 May 25.
Org Biomol Chem. 2004.
PMID: 15188040
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Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.
Masini T, Lacy B, Monjas L, Hawksley D, de Voogd AR, Illarionov B, Iqbal A, Leeper FJ, Fischer M, Kontoyianni M, Hirsch AK.
Masini T, et al. Among authors: hawksley d.
Org Biomol Chem. 2015 Dec 14;13(46):11263-77. doi: 10.1039/c5ob01666e. Epub 2015 Sep 28.
Org Biomol Chem. 2015.
PMID: 26411373
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Studies on thiamine diphosphate-dependent enzymes.
Leeper FJ, Hawksley D, Mann S, Perez Melero C, Wood MD.
Leeper FJ, et al. Among authors: hawksley d.
Biochem Soc Trans. 2005 Aug;33(Pt 4):772-5. doi: 10.1042/BST0330772.
Biochem Soc Trans. 2005.
PMID: 16042596
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Focus on success: using a probabilistic approach to achieve an optimal balance of compound properties in drug discovery.
Segall MD, Beresford AP, Gola JM, Hawksley D, Tarbit MH.
Segall MD, et al. Among authors: hawksley d.
Expert Opin Drug Metab Toxicol. 2006 Apr;2(2):325-37. doi: 10.1517/17425255.2.2.325.
Expert Opin Drug Metab Toxicol. 2006.
PMID: 16866617
Review.
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