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Structure of a eukaryotic thiaminase I.
Kreinbring CA, Remillard SP, Hubbard P, Brodkin HR, Leeper FJ, Hawksley D, Lai EY, Fulton C, Petsko GA, Ringe D. Kreinbring CA, et al. Among authors: leeper fj. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):137-42. doi: 10.1073/pnas.1315882110. Epub 2013 Dec 18. Proc Natl Acad Sci U S A. 2014. PMID: 24351929 Free PMC article.
Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.
Masini T, Lacy B, Monjas L, Hawksley D, de Voogd AR, Illarionov B, Iqbal A, Leeper FJ, Fischer M, Kontoyianni M, Hirsch AK. Masini T, et al. Among authors: leeper fj. Org Biomol Chem. 2015 Dec 14;13(46):11263-77. doi: 10.1039/c5ob01666e. Epub 2015 Sep 28. Org Biomol Chem. 2015. PMID: 26411373
Studies on thiamine diphosphate-dependent enzymes.
Leeper FJ, Hawksley D, Mann S, Perez Melero C, Wood MD. Leeper FJ, et al. Biochem Soc Trans. 2005 Aug;33(Pt 4):772-5. doi: 10.1042/BST0330772. Biochem Soc Trans. 2005. PMID: 16042596
Structure of the branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis provides insights into the structural basis for the chemoselective and enantioselective carboligation reaction.
Berthold CL, Gocke D, Wood MD, Leeper FJ, Pohl M, Schneider G. Berthold CL, et al. Among authors: leeper fj. Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1217-24. doi: 10.1107/S0907444907050433. Epub 2007 Nov 16. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 18084069
76 results