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K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
Harikumar KB, Yester JW, Surace MJ, Oyeniran C, Price MM, Huang WC, Hait NC, Allegood JC, Yamada A, Kong X, Lazear HM, Bhardwaj R, Takabe K, Diamond MS, Luo C, Milstien S, Spiegel S, Kordula T. Harikumar KB, et al. Among authors: allegood jc. Nat Immunol. 2014 Mar;15(3):231-8. doi: 10.1038/ni.2810. Epub 2014 Jan 26. Nat Immunol. 2014. PMID: 24464131 Free PMC article.
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.
Price MM, Oskeritzian CA, Falanga YT, Harikumar KB, Allegood JC, Alvarez SE, Conrad D, Ryan JJ, Milstien S, Spiegel S. Price MM, et al. Among authors: allegood jc. J Allergy Clin Immunol. 2013 Feb;131(2):501-11.e1. doi: 10.1016/j.jaci.2012.07.014. Epub 2012 Aug 30. J Allergy Clin Immunol. 2013. PMID: 22939756 Free PMC article.
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Liang J, Nagahashi M, Kim EY, Harikumar KB, Yamada A, Huang WC, Hait NC, Allegood JC, Price MM, Avni D, Takabe K, Kordula T, Milstien S, Spiegel S. Liang J, et al. Among authors: allegood jc. Cancer Cell. 2013 Jan 14;23(1):107-20. doi: 10.1016/j.ccr.2012.11.013. Epub 2012 Dec 27. Cancer Cell. 2013. PMID: 23273921 Free PMC article.
Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.
Oyeniran C, Sturgill JL, Hait NC, Huang WC, Avni D, Maceyka M, Newton J, Allegood JC, Montpetit A, Conrad DH, Milstien S, Spiegel S. Oyeniran C, et al. Among authors: allegood jc. J Allergy Clin Immunol. 2015 Oct;136(4):1035-46.e6. doi: 10.1016/j.jaci.2015.02.031. Epub 2015 Apr 2. J Allergy Clin Immunol. 2015. PMID: 25842287 Free PMC article.
89 results