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Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial.
Le Lamer S, Paradis S, Rahmouni H, Chaimbault C, Michaud M, Culcasi M, Afxantidis J, Latreille M, Berna P, Berdeaux A, Pietri S, Morin D, Donazzolo Y, Abitbol JL, Pruss RM, Schaller S. Le Lamer S, et al. Among authors: michaud m. J Transl Med. 2014 Feb 7;12:38. doi: 10.1186/1479-5876-12-38. J Transl Med. 2014. PMID: 24507657 Free PMC article. Clinical Trial.
Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.
Richter F, Gao F, Medvedeva V, Lee P, Bove N, Fleming SM, Michaud M, Lemesre V, Patassini S, De La Rosa K, Mulligan CK, Sioshansi PC, Zhu C, Coppola G, Bordet T, Pruss RM, Chesselet MF. Richter F, et al. Among authors: michaud m. Neurobiol Dis. 2014 Sep;69:263-75. doi: 10.1016/j.nbd.2014.05.012. Epub 2014 May 18. Neurobiol Dis. 2014. PMID: 24844147 Free PMC article.
Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.
Clemens LE, Weber JJ, Wlodkowski TT, Yu-Taeger L, Michaud M, Calaminus C, Eckert SH, Gaca J, Weiss A, Magg JC, Jansson EK, Eckert GP, Pichler BJ, Bordet T, Pruss RM, Riess O, Nguyen HP. Clemens LE, et al. Among authors: michaud m. Brain. 2015 Dec;138(Pt 12):3632-53. doi: 10.1093/brain/awv290. Epub 2015 Oct 21. Brain. 2015. PMID: 26490331
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.
Bordet T, Buisson B, Michaud M, Drouot C, Galéa P, Delaage P, Akentieva NP, Evers AS, Covey DF, Ostuni MA, Lacapère JJ, Massaad C, Schumacher M, Steidl EM, Maux D, Delaage M, Henderson CE, Pruss RM. Bordet T, et al. Among authors: michaud m. J Pharmacol Exp Ther. 2007 Aug;322(2):709-20. doi: 10.1124/jpet.107.123000. Epub 2007 May 11. J Pharmacol Exp Ther. 2007. PMID: 17496168
416 results