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An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solution.
Waddington CS, Darton TC, Jones C, Haworth K, Peters A, John T, Thompson BA, Kerridge SA, Kingsley RA, Zhou L, Holt KE, Yu LM, Lockhart S, Farrar JJ, Sztein MB, Dougan G, Angus B, Levine MM, Pollard AJ. Waddington CS, et al. Among authors: dougan g. Clin Infect Dis. 2014 May;58(9):1230-40. doi: 10.1093/cid/ciu078. Epub 2014 Feb 10. Clin Infect Dis. 2014. PMID: 24519873 Free PMC article.
Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.
Toapanta FR, Bernal PJ, Fresnay S, Darton TC, Jones C, Waddington CS, Blohmke CJ, Dougan G, Angus B, Levine MM, Pollard AJ, Sztein MB. Toapanta FR, et al. Among authors: dougan g. PLoS Negl Trop Dis. 2015 Jun 11;9(6):e0003837. doi: 10.1371/journal.pntd.0003837. eCollection 2015 Jun. PLoS Negl Trop Dis. 2015. PMID: 26065687 Free PMC article.
Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.
Blohmke CJ, Darton TC, Jones C, Suarez NM, Waddington CS, Angus B, Zhou L, Hill J, Clare S, Kane L, Mukhopadhyay S, Schreiber F, Duque-Correa MA, Wright JC, Roumeliotis TI, Yu L, Choudhary JS, Mejias A, Ramilo O, Shanyinde M, Sztein MB, Kingsley RA, Lockhart S, Levine MM, Lynn DJ, Dougan G, Pollard AJ. Blohmke CJ, et al. Among authors: dougan g. J Exp Med. 2016 May 30;213(6):1061-77. doi: 10.1084/jem.20151025. Epub 2016 May 23. J Exp Med. 2016. PMID: 27217537 Free PMC article. Clinical Trial.
Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.
Darton TC, Jones C, Blohmke CJ, Waddington CS, Zhou L, Peters A, Haworth K, Sie R, Green CA, Jeppesen CA, Moore M, Thompson BA, John T, Kingsley RA, Yu LM, Voysey M, Hindle Z, Lockhart S, Sztein MB, Dougan G, Angus B, Levine MM, Pollard AJ. Darton TC, et al. Among authors: dougan g. PLoS Negl Trop Dis. 2016 Aug 17;10(8):e0004926. doi: 10.1371/journal.pntd.0004926. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27533046 Free PMC article. Clinical Trial.
An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever.
Tran Vu Thieu N, Trinh Van T, Tran Tuan A, Klemm EJ, Nguyen Ngoc Minh C, Voong Vinh P, Pham Thanh D, Ho Ngoc Dan T, Pham Duc T, Langat P, Martin LB, Galan J, Liang L, Felgner PL, Davies DH, de Jong HK, Maude RR, Fukushima M, Wijedoru L, Ghose A, Samad R, Dondorp AM, Faiz A, Darton TC, Pollard AJ, Thwaites GE, Dougan G, Parry CM, Baker S. Tran Vu Thieu N, et al. Among authors: dougan g. J Infect. 2017 Aug;75(2):104-114. doi: 10.1016/j.jinf.2017.05.007. Epub 2017 May 25. J Infect. 2017. PMID: 28551371 Free PMC article.
The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26-27 October 2016, Oxford, UK.
Meiring JE, Gibani M; TyVAC Consortium Meeting Group:. Meiring JE, et al. Vaccine. 2017 Sep 12;35(38):5081-5088. doi: 10.1016/j.vaccine.2017.08.001. Epub 2017 Aug 10. Vaccine. 2017. PMID: 28802757 Free article.
Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy.
Britto CD, Dyson ZA, Duchene S, Carter MJ, Gurung M, Kelly DF, Murdoch DR, Ansari I, Thorson S, Shrestha S, Adhikari N, Dougan G, Holt KE, Pollard AJ. Britto CD, et al. Among authors: dougan g. PLoS Negl Trop Dis. 2018 Apr 23;12(4):e0006408. doi: 10.1371/journal.pntd.0006408. eCollection 2018 Apr. PLoS Negl Trop Dis. 2018. PMID: 29684021 Free PMC article.
Determining the Best Immunization Strategy for Protecting African Children Against Invasive Salmonella Disease.
Jeon HJ, Pak GD, Im J, Owusu-Dabo E, Adu-Sarkodie Y, Gassama Sow A, Bassiahi Soura A, Gasmelseed N, Keddy KH, Bjerregaard-Andersen M, Konings F, Aseffa A, Crump JA, Chon Y, Breiman RF, Park SE, Cruz Espinoza LM, Seo HJ, May J, Meyer CG, Andrews JR, Panzner U, von Kalckreuth V, Wierzba TF, Rakotozandrindrainy R, Dougan G, Levine MM, Hombach J, Kim JH, Clemens JD, Baker S, Marks F. Jeon HJ, et al. Among authors: dougan g. Clin Infect Dis. 2018 Nov 28;67(12):1824-1830. doi: 10.1093/cid/ciy386. Clin Infect Dis. 2018. PMID: 29746615 Free PMC article.
Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model.
Gibani MM, Jones E, Barton A, Jin C, Meek J, Camara S, Galal U, Heinz E, Rosenberg-Hasson Y, Obermoser G, Jones C, Campbell D, Black C, Thomaides-Brears H, Darlow C, Dold C, Silva-Reyes L, Blackwell L, Lara-Tejero M, Jiao X, Stack G, Blohmke CJ, Hill J, Angus B, Dougan G, Galán J, Pollard AJ. Gibani MM, et al. Among authors: dougan g. Nat Med. 2019 Jul;25(7):1082-1088. doi: 10.1038/s41591-019-0505-4. Epub 2019 Jul 3. Nat Med. 2019. PMID: 31270506 Free PMC article. Clinical Trial.
755 results