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An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solution.
Waddington CS, Darton TC, Jones C, Haworth K, Peters A, John T, Thompson BA, Kerridge SA, Kingsley RA, Zhou L, Holt KE, Yu LM, Lockhart S, Farrar JJ, Sztein MB, Dougan G, Angus B, Levine MM, Pollard AJ. Waddington CS, et al. Among authors: lockhart s. Clin Infect Dis. 2014 May;58(9):1230-40. doi: 10.1093/cid/ciu078. Epub 2014 Feb 10. Clin Infect Dis. 2014. PMID: 24519873 Free PMC article.
A randomized study comparing the safety and immunogenicity of a conjugate vaccine combination containing meningococcal group C and pneumococcal capsular polysaccharide--CRM197 with a meningococcal group C conjugate vaccine in healthy infants: challenge phase.
Riddell A, Buttery JP, McVernon J, Chantler T, Lane L, Bowen-Morris J, Diggle L, Morris R, Lockhart S, Pollard AJ, Cartwright K, Moxon ER. Riddell A, et al. Among authors: lockhart s. Vaccine. 2007 May 10;25(19):3906-12. doi: 10.1016/j.vaccine.2007.01.097. Epub 2007 Feb 7. Vaccine. 2007. PMID: 17368663 Clinical Trial.
Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.
Blohmke CJ, Darton TC, Jones C, Suarez NM, Waddington CS, Angus B, Zhou L, Hill J, Clare S, Kane L, Mukhopadhyay S, Schreiber F, Duque-Correa MA, Wright JC, Roumeliotis TI, Yu L, Choudhary JS, Mejias A, Ramilo O, Shanyinde M, Sztein MB, Kingsley RA, Lockhart S, Levine MM, Lynn DJ, Dougan G, Pollard AJ. Blohmke CJ, et al. Among authors: lockhart s. J Exp Med. 2016 May 30;213(6):1061-77. doi: 10.1084/jem.20151025. Epub 2016 May 23. J Exp Med. 2016. PMID: 27217537 Free PMC article. Clinical Trial.
Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.
Darton TC, Jones C, Blohmke CJ, Waddington CS, Zhou L, Peters A, Haworth K, Sie R, Green CA, Jeppesen CA, Moore M, Thompson BA, John T, Kingsley RA, Yu LM, Voysey M, Hindle Z, Lockhart S, Sztein MB, Dougan G, Angus B, Levine MM, Pollard AJ. Darton TC, et al. Among authors: lockhart s. PLoS Negl Trop Dis. 2016 Aug 17;10(8):e0004926. doi: 10.1371/journal.pntd.0004926. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27533046 Free PMC article. Clinical Trial.
A Phase 2 Extension Study Evaluating the Immunogenicity, Safety, and Tolerability of 3 or 4 Doses of a Clostridioides difficile Vaccine in Healthy US Adults Aged 65 to 85 Years.
Remich S, Kitchin N, Peterson J, Li P, Pride MW, Brock L, Anderson AS, Gruber WC, Jansen KU, Lockhart SP, Webber C. Remich S, et al. Among authors: lockhart sp. J Infect Dis. 2024 Feb 14;229(2):367-375. doi: 10.1093/infdis/jiad307. J Infect Dis. 2024. PMID: 37531657 Free PMC article. Clinical Trial.
Comparison of pneumococcal conjugate polysaccharide and free polysaccharide vaccines in elderly adults: conjugate vaccine elicits improved antibacterial immune responses and immunological memory.
de Roux A, Schmöle-Thoma B, Siber GR, Hackell JG, Kuhnke A, Ahlers N, Baker SA, Razmpour A, Emini EA, Fernsten PD, Gruber WC, Lockhart S, Burkhardt O, Welte T, Lode HM. de Roux A, et al. Among authors: lockhart s. Clin Infect Dis. 2008 Apr 1;46(7):1015-23. doi: 10.1086/529142. Clin Infect Dis. 2008. PMID: 18444818
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