Wetzel R - Search Results

1

Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen.

Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher CD, Gagsteiger F, Fändrich M, Kirchhoff F, Münch J. Usmani SM, et al. Among authors: wetzel r. Nat Commun. 2014 Apr 1;5:3508. doi: 10.1038/ncomms4508. Nat Commun. 2014. PMID: 24691351 Free PMC article.

2

Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway.

Misra P, Kodali R, Chemuru S, Kar K, Wetzel R. Misra P, et al. Among authors: wetzel r. Nat Commun. 2016 Aug 22;7:12419. doi: 10.1038/ncomms12419. Nat Commun. 2016. PMID: 27546208 Free PMC article.

3

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core.

Lin HK, Boatz JC, Krabbendam IE, Kodali R, Hou Z, Wetzel R, Dolga AM, Poirier MA, van der Wel PCA. Lin HK, et al. Among authors: wetzel r. Nat Commun. 2017 May 24;8:15462. doi: 10.1038/ncomms15462. Nat Commun. 2017. PMID: 28537272 Free PMC article.

4

β-hairpin-mediated nucleation of polyglutamine amyloid formation.

Kar K, Hoop CL, Drombosky KW, Baker MA, Kodali R, Arduini I, van der Wel PC, Horne WS, Wetzel R. Kar K, et al. Among authors: wetzel r. J Mol Biol. 2013 Apr 12;425(7):1183-97. doi: 10.1016/j.jmb.2013.01.016. Epub 2013 Jan 23. J Mol Biol. 2013. PMID: 23353826 Free PMC article.

5

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.

Thakur AK, Jayaraman M, Mishra R, Thakur M, Chellgren VM, Byeon IJ, Anjum DH, Kodali R, Creamer TP, Conway JF, Gronenborn AM, Wetzel R. Thakur AK, et al. Among authors: wetzel r. Nat Struct Mol Biol. 2009 Apr;16(4):380-9. doi: 10.1038/nsmb.1570. Epub 2009 Mar 8. Nat Struct Mol Biol. 2009. PMID: 19270701 Free PMC article.

6

Soluble and mature amyloid fibrils in drusen deposits.

Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe CG, Langen R, Chen J. Isas JM, et al. Among authors: wetzel r. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1304-10. doi: 10.1167/iovs.09-4207. Epub 2009 Nov 5. Invest Ophthalmol Vis Sci. 2010. PMID: 19892876 Free PMC article.

7

The aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils.

Sivanandam VN, Jayaraman M, Hoop CL, Kodali R, Wetzel R, van der Wel PC. Sivanandam VN, et al. Among authors: wetzel r. J Am Chem Soc. 2011 Mar 30;133(12):4558-66. doi: 10.1021/ja110715f. Epub 2011 Mar 7. J Am Chem Soc. 2011. PMID: 21381744 Free PMC article.

8

Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent.

Kar K, Jayaraman M, Sahoo B, Kodali R, Wetzel R. Kar K, et al. Among authors: wetzel r. Nat Struct Mol Biol. 2011 Mar;18(3):328-36. doi: 10.1038/nsmb.1992. Epub 2011 Feb 13. Nat Struct Mol Biol. 2011. PMID: 21317897 Free PMC article.

9

Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance.

Hoop CL, Lin HK, Kar K, Hou Z, Poirier MA, Wetzel R, van der Wel PC. Hoop CL, et al. Among authors: wetzel r. Biochemistry. 2014 Oct 28;53(42):6653-66. doi: 10.1021/bi501010q. Epub 2014 Oct 16. Biochemistry. 2014. PMID: 25280367 Free PMC article.

10

Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties.

Jayaraman M, Mishra R, Kodali R, Thakur AK, Koharudin LM, Gronenborn AM, Wetzel R. Jayaraman M, et al. Among authors: wetzel r. Biochemistry. 2012 Apr 3;51(13):2706-16. doi: 10.1021/bi3000929. Epub 2012 Mar 20. Biochemistry. 2012. PMID: 22432740 Free PMC article.

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