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Predicting the virulence of MRSA from its genome sequence.
Laabei M, Recker M, Rudkin JK, Aldeljawi M, Gulay Z, Sloan TJ, Williams P, Endres JL, Bayles KW, Fey PD, Yajjala VK, Widhelm T, Hawkins E, Lewis K, Parfett S, Scowen L, Peacock SJ, Holden M, Wilson D, Read TD, van den Elsen J, Priest NK, Feil EJ, Hurst LD, Josefsson E, Massey RC. Laabei M, et al. Among authors: holden m. Genome Res. 2014 May;24(5):839-49. doi: 10.1101/gr.165415.113. Epub 2014 Apr 9. Genome Res. 2014. PMID: 24717264 Free PMC article.
The impact of recombination on dN/dS within recently emerged bacterial clones.
Castillo-Ramírez S, Harris SR, Holden MT, He M, Parkhill J, Bentley SD, Feil EJ. Castillo-Ramírez S, et al. Among authors: holden mt. PLoS Pathog. 2011 Jul;7(7):e1002129. doi: 10.1371/journal.ppat.1002129. Epub 2011 Jul 14. PLoS Pathog. 2011. PMID: 21779170 Free PMC article.
Rapid whole-genome sequencing for investigation of a neonatal MRSA outbreak.
Köser CU, Holden MT, Ellington MJ, Cartwright EJ, Brown NM, Ogilvy-Stuart AL, Hsu LY, Chewapreecha C, Croucher NJ, Harris SR, Sanders M, Enright MC, Dougan G, Bentley SD, Parkhill J, Fraser LJ, Betley JR, Schulz-Trieglaff OB, Smith GP, Peacock SJ. Köser CU, et al. Among authors: holden mt. N Engl J Med. 2012 Jun 14;366(24):2267-75. doi: 10.1056/NEJMoa1109910. N Engl J Med. 2012. PMID: 22693998 Free PMC article.
Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting.
Tong SY, Holden MT, Nickerson EK, Cooper BS, Köser CU, Cori A, Jombart T, Cauchemez S, Fraser C, Wuthiekanun V, Thaipadungpanit J, Hongsuwan M, Day NP, Limmathurotsakul D, Parkhill J, Peacock SJ. Tong SY, et al. Among authors: holden mt. Genome Res. 2015 Jan;25(1):111-8. doi: 10.1101/gr.174730.114. Epub 2014 Dec 9. Genome Res. 2015. PMID: 25491771 Free PMC article.
Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus.
Laabei M, Uhlemann AC, Lowy FD, Austin ED, Yokoyama M, Ouadi K, Feil E, Thorpe HA, Williams B, Perkins M, Peacock SJ, Clarke SR, Dordel J, Holden M, Votintseva AA, Bowden R, Crook DW, Young BC, Wilson DJ, Recker M, Massey RC. Laabei M, et al. Among authors: holden m. PLoS Biol. 2015 Sep 2;13(9):e1002229. doi: 10.1371/journal.pbio.1002229. eCollection 2015. PLoS Biol. 2015. PMID: 26331877 Free PMC article.
A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.
Holden MT, Hsu LY, Kurt K, Weinert LA, Mather AE, Harris SR, Strommenger B, Layer F, Witte W, de Lencastre H, Skov R, Westh H, Zemlicková H, Coombs G, Kearns AM, Hill RL, Edgeworth J, Gould I, Gant V, Cooke J, Edwards GF, McAdam PR, Templeton KE, McCann A, Zhou Z, Castillo-Ramírez S, Feil EJ, Hudson LO, Enright MC, Balloux F, Aanensen DM, Spratt BG, Fitzgerald JR, Parkhill J, Achtman M, Bentley SD, Nübel U. Holden MT, et al. Genome Res. 2013 Apr;23(4):653-64. doi: 10.1101/gr.147710.112. Epub 2013 Jan 8. Genome Res. 2013. PMID: 23299977 Free PMC article.
Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns.
Donker T, Reuter S, Scriberras J, Reynolds R, Brown NM, Török ME, James R, Network EOEMR, Aanensen DM, Bentley SD, Holden MTG, Parkhill J, Spratt BG, Peacock SJ, Feil EJ, Grundmann H. Donker T, et al. Among authors: holden mtg. Microb Genom. 2017 Jul 4;3(7):e000113. doi: 10.1099/mgen.0.000113. eCollection 2017 Jul. Microb Genom. 2017. PMID: 29026654 Free PMC article.
Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.
Holden MT, Feil EJ, Lindsay JA, Peacock SJ, Day NP, Enright MC, Foster TJ, Moore CE, Hurst L, Atkin R, Barron A, Bason N, Bentley SD, Chillingworth C, Chillingworth T, Churcher C, Clark L, Corton C, Cronin A, Doggett J, Dowd L, Feltwell T, Hance Z, Harris B, Hauser H, Holroyd S, Jagels K, James KD, Lennard N, Line A, Mayes R, Moule S, Mungall K, Ormond D, Quail MA, Rabbinowitsch E, Rutherford K, Sanders M, Sharp S, Simmonds M, Stevens K, Whitehead S, Barrell BG, Spratt BG, Parkhill J. Holden MT, et al. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9786-91. doi: 10.1073/pnas.0402521101. Epub 2004 Jun 22. Proc Natl Acad Sci U S A. 2004. PMID: 15213324 Free PMC article.
818 results