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Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression.
Uzan B, Poglio S, Gerby B, Wu CL, Gross J, Armstrong F, Calvo J, Cahu X, Deswarte C, Dumont F, Passaro D, Besnard-Guérin C, Leblanc T, Baruchel A, Landman-Parker J, Ballerini P, Baud V, Ghysdael J, Baleydier F, Porteu F, Pflumio F. Uzan B, et al. Among authors: ballerini p. EMBO Mol Med. 2014 Jun;6(6):821-34. doi: 10.1002/emmm.201303286. Epub 2014 Apr 6. EMBO Mol Med. 2014. PMID: 24778454 Free PMC article.
NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity.
Armstrong F, Brunet de la Grange P, Gerby B, Rouyez MC, Calvo J, Fontenay M, Boissel N, Dombret H, Baruchel A, Landman-Parker J, Roméo PH, Ballerini P, Pflumio F. Armstrong F, et al. Among authors: ballerini p. Blood. 2009 Feb 19;113(8):1730-40. doi: 10.1182/blood-2008-02-138172. Epub 2008 Nov 4. Blood. 2009. PMID: 18984862 Free article.
Bone marrow sites differently imprint dormancy and chemoresistance to T-cell acute lymphoblastic leukemia.
Cahu X, Calvo J, Poglio S, Prade N, Colsch B, Arcangeli ML, Leblanc T, Petit A, Baleydier F, Baruchel A, Landman-Parker J, Junot C, Larghero J, Ballerini P, Delabesse E, Uzan B, Pflumio F. Cahu X, et al. Among authors: ballerini p. Blood Adv. 2017 Sep 8;1(20):1760-1772. doi: 10.1182/bloodadvances.2017004960. eCollection 2017 Sep 12. Blood Adv. 2017. PMID: 29296822 Free PMC article.
T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7.
Buffière A, Uzan B, Aucagne R, Hermetet F, Mas M, Nassurdine S, Aznague A, Carmignac V, Tournier B, Bouchot O, Ballerini P, Barata JT, Bastie JN, Delva L, Pflumio F, Quéré R. Buffière A, et al. Among authors: ballerini p. Oncogene. 2019 Nov;38(48):7357-7365. doi: 10.1038/s41388-019-0921-4. Epub 2019 Aug 15. Oncogene. 2019. PMID: 31417180
Hypoxia favors chemoresistance in T-ALL through an HIF1α-mediated mTORC1 inhibition loop.
Fahy L, Calvo J, Chabi S, Renou L, Le Maout C, Poglio S, Leblanc T, Petit A, Baruchel A, Ballerini P, Naguibneva I, Haddad R, Arcangeli ML, Mazurier F, Pflumio F, Uzan B. Fahy L, et al. Among authors: ballerini p. Blood Adv. 2021 Jan 26;5(2):513-526. doi: 10.1182/bloodadvances.2020002832. Blood Adv. 2021. PMID: 33496749 Free PMC article.
SPRED1, a RAS MAPK pathway inhibitor that causes Legius syndrome, is a tumour suppressor downregulated in paediatric acute myeloblastic leukaemia.
Pasmant E, Gilbert-Dussardier B, Petit A, de Laval B, Luscan A, Gruber A, Lapillonne H, Deswarte C, Goussard P, Laurendeau I, Uzan B, Pflumio F, Brizard F, Vabres P, Naguibvena I, Fasola S, Millot F, Porteu F, Vidaud D, Landman-Parker J, Ballerini P. Pasmant E, et al. Among authors: ballerini p. Oncogene. 2015 Jan 29;34(5):631-8. doi: 10.1038/onc.2013.587. Epub 2014 Jan 27. Oncogene. 2015. PMID: 24469042
212 results