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A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis.
Gómez-Galeno JE, Dang Q, Nguyen TH, Boyer SH, Grote MP, Sun Z, Chen M, Craigo WA, van Poelje PD, MacKenna DA, Cable EE, Rolzin PA, Finn PD, Chi B, Linemeyer DL, Hecker SJ, Erion MD. Gómez-Galeno JE, et al. Among authors: linemeyer dl. ACS Med Chem Lett. 2010 Aug 30;1(9):478-82. doi: 10.1021/ml100143q. eCollection 2010 Dec 9. ACS Med Chem Lett. 2010. PMID: 24900234 Free PMC article.
Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys.
Ito BR, Zhang BH, Cable EE, Song X, Fujitaki JM, MacKenna DA, Wilker CE, Chi B, van Poelje PD, Linemeyer DL, Erion MD. Ito BR, et al. Among authors: linemeyer dl. Br J Pharmacol. 2009 Feb;156(3):454-65. doi: 10.1111/j.1750-3639.2009.00038.x. Epub 2009 Jan 22. Br J Pharmacol. 2009. PMID: 19183199 Free PMC article.
Liver-targeted drug delivery using HepDirect prodrugs.
Erion MD, van Poelje PD, Mackenna DA, Colby TJ, Montag AC, Fujitaki JM, Linemeyer DL, Bullough DA. Erion MD, et al. Among authors: linemeyer dl. J Pharmacol Exp Ther. 2005 Feb;312(2):554-60. doi: 10.1124/jpet.104.075903. Epub 2004 Aug 31. J Pharmacol Exp Ther. 2005. PMID: 15340017
Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index.
Erion MD, Cable EE, Ito BR, Jiang H, Fujitaki JM, Finn PD, Zhang BH, Hou J, Boyer SH, van Poelje PD, Linemeyer DL. Erion MD, et al. Among authors: linemeyer dl. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5. doi: 10.1073/pnas.0702759104. Epub 2007 Sep 18. Proc Natl Acad Sci U S A. 2007. PMID: 17878314 Free PMC article.
Antiviral efficacy upon administration of a HepDirect prodrug of 2'-C-methylcytidine to hepatitis C virus-infected chimpanzees.
Carroll SS, Koeplinger K, Vavrek M, Zhang NR, Handt L, MacCoss M, Olsen DB, Reddy KR, Sun Z, van Poelje PD, Fujitaki JM, Boyer SH, Linemeyer DL, Hecker SJ, Erion MD. Carroll SS, et al. Among authors: linemeyer dl. Antimicrob Agents Chemother. 2011 Aug;55(8):3854-60. doi: 10.1128/AAC.01152-10. Epub 2011 May 31. Antimicrob Agents Chemother. 2011. PMID: 21628542 Free PMC article.
Cloning and expression of a novel neuropeptide Y receptor.
Weinberg DH, Sirinathsinghji DJ, Tan CP, Shiao LL, Morin N, Rigby MR, Heavens RH, Rapoport DR, Bayne ML, Cascieri MA, Strader CD, Linemeyer DL, MacNeil DJ. Weinberg DH, et al. Among authors: linemeyer dl. J Biol Chem. 1996 Jul 12;271(28):16435-8. doi: 10.1074/jbc.271.28.16435. J Biol Chem. 1996. PMID: 8663568 Free article.
35 results