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Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice.
Bartesaghi S, Wallenius K, Hovdal D, Liljeblad M, Wallin S, Dekker N, Barlind L, Davies N, Seeliger F, Winzell MS, Patel S, Theisen M, Brito L, Bergenhem N, Andersson S, Peng XR. Bartesaghi S, et al. Among authors: seeliger f. Mol Ther Nucleic Acids. 2022 Apr 18;28:500-513. doi: 10.1016/j.omtn.2022.04.010. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35592498 Free PMC article.
Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat.
Berg S, Kärrberg L, Suljovic D, Seeliger F, Söderberg M, Perez-Alcazar M, Van Zuydam N, Abrahamsson B, Hugerth AM, Davies N, Bergström CAS. Berg S, et al. Among authors: seeliger f. Mol Pharm. 2022 Jan 3;19(1):200-212. doi: 10.1021/acs.molpharmaceut.1c00724. Epub 2021 Dec 20. Mol Pharm. 2022. PMID: 34928160 Free PMC article.
Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging.
Strittmatter N, Kanvatirth P, Inglese P, Race AM, Nilsson A, Dannhorn A, Kudo H, Goldin RD, Ling S, Wong E, Seeliger F, Serra MP, Hoffmann S, Maglennon G, Hamm G, Atkinson J, Jones S, Bunch J, Andrén PE, Takats Z, Goodwin RJA, Mastroeni P. Strittmatter N, et al. Among authors: seeliger f. J Am Soc Mass Spectrom. 2021 Dec 1;32(12):2791-2802. doi: 10.1021/jasms.1c00240. Epub 2021 Nov 12. J Am Soc Mass Spectrom. 2021. PMID: 34767352
Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein.
Davies N, Hovdal D, Edmunds N, Nordberg P, Dahlén A, Dabkowska A, Arteta MY, Radulescu A, Kjellman T, Höijer A, Seeliger F, Holmedal E, Andihn E, Bergenhem N, Sandinge AS, Johansson C, Hultin L, Johansson M, Lindqvist J, Björsson L, Jing Y, Bartesaghi S, Lindfors L, Andersson S. Davies N, et al. Among authors: seeliger f. Mol Ther Nucleic Acids. 2021 Mar 13;24:369-384. doi: 10.1016/j.omtn.2021.03.008. eCollection 2021 Jun 4. Mol Ther Nucleic Acids. 2021. PMID: 33868782 Free PMC article.
Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery.
Lundin A, Porritt MJ, Jaiswal H, Seeliger F, Johansson C, Bidar AW, Badertscher L, Wimberger S, Davies EJ, Hardaker E, Martins CP, James E, Admyre T, Taheri-Ghahfarokhi A, Bradley J, Schantz A, Alaeimahabadi B, Clausen M, Xu X, Mayr LM, Nitsch R, Bohlooly-Y M, Barry ST, Maresca M. Lundin A, et al. Among authors: seeliger f. Nat Commun. 2020 Sep 29;11(1):4903. doi: 10.1038/s41467-020-18548-9. Nat Commun. 2020. PMID: 32994412 Free PMC article.
A MALT1 inhibitor suppresses human myeloid DC, effector T-cell and B-cell responses and retains Th1/regulatory T-cell homeostasis.
Dumont C, Sivars U, Andreasson T, Odqvist L, Mattsson J, DeMicco A, Pardali K, Johansson G, Yrlid L, Cox RJ, Seeliger F, Larsson M, Gehrmann U, Davis AM, Vaarala O. Dumont C, et al. Among authors: seeliger f. PLoS One. 2020 Sep 1;15(9):e0222548. doi: 10.1371/journal.pone.0222548. eCollection 2020. PLoS One. 2020. PMID: 32870913 Free PMC article.
IDOL regulates systemic energy balance through control of neuronal VLDLR expression.
Lee SD, Priest C, Bjursell M, Gao J, Arneson DV, Ahn IS, Diamante G, van Veen JE, Massa MG, Calkin AC, Kim J, Andersén H, Rajbhandari P, Porritt M, Carreras A, Ahnmark A, Seeliger F, Maxvall I, Eliasson P, Althage M, Åkerblad P, Lindén D, Cole TA, Lee R, Boyd H, Bohlooly-Y M, Correa SM, Yang X, Tontonoz P, Hong C. Lee SD, et al. Among authors: seeliger f. Nat Metab. 2019 Nov;1(11):1089-1100. doi: 10.1038/s42255-019-0127-7. Epub 2019 Oct 28. Nat Metab. 2019. PMID: 32072135 Free PMC article.
In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model.
Carreras A, Pane LS, Nitsch R, Madeyski-Bengtson K, Porritt M, Akcakaya P, Taheri-Ghahfarokhi A, Ericson E, Bjursell M, Perez-Alcazar M, Seeliger F, Althage M, Knöll R, Hicks R, Mayr LM, Perkins R, Lindén D, Borén J, Bohlooly-Y M, Maresca M. Carreras A, et al. Among authors: seeliger f. BMC Biol. 2019 Jan 15;17(1):4. doi: 10.1186/s12915-018-0624-2. BMC Biol. 2019. PMID: 30646909 Free PMC article.
43 results