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Tau in the brain interstitial fluid is fragmented and seeding-competent.
Barini E, Plotzky G, Mordashova Y, Hoppe J, Rodriguez-Correa E, Julier S, LePrieult F, Mairhofer I, Mezler M, Biesinger S, Cik M, Meinhardt MW, Ercan-Herbst E, Ehrnhoefer DE, Striebinger A, Bodie K, Klein C, Gasparini L, Schlegel K. Barini E, et al. Among authors: klein c. Neurobiol Aging. 2022 Jan;109:64-77. doi: 10.1016/j.neurobiolaging.2021.09.013. Epub 2021 Sep 17. Neurobiol Aging. 2022. PMID: 34655982 Free article.
Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation.
Reinhardt L, Musacchio F, Bichmann M, Behrendt A, Ercan-Herbst E, Stein J, Becher I, Haberkant P, Mader J, Schöndorf DC, Schmitt M, Korffmann J, Reinhardt P, Pohl C, Savitski M, Klein C, Gasparini L, Fuhrmann M, Ehrnhoefer DE. Reinhardt L, et al. Among authors: klein c. Neurobiol Dis. 2023 Jun 15;182:106126. doi: 10.1016/j.nbd.2023.106126. Epub 2023 Apr 20. Neurobiol Dis. 2023. PMID: 37086756 Free article.
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau.
Wachter A, Woodbury ME, Lombardo S, Abdourahman A, Wuest C, McGlame E, Pastika T, Tamm J, Romanul N, Yanamandra K, Bennett R, Lin G, Kwon T, Liao F, Klein C, Grinberg Y, Jaisa-Aad M, Li H, Frosch MP, Kummer MP, Das S, Dellovade T, Karran EH, Langlois X, Ried JS, Serrano-Pozo A, Talanian RV, Biber K, Hyman BT. Wachter A, et al. Among authors: klein c. Acta Neuropathol. 2024 Apr 1;147(1):65. doi: 10.1007/s00401-024-02704-2. Acta Neuropathol. 2024. PMID: 38557897 Free PMC article.
Development of disease-modifying treatment of schizophrenia.
Bespalov A, Klein C, Behl B, Gross G, Schoemaker H. Bespalov A, et al. Among authors: klein c. Handb Exp Pharmacol. 2012;(213):419-42. doi: 10.1007/978-3-642-25758-2_14. Handb Exp Pharmacol. 2012. PMID: 23027423 Review.
Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models.
Huang L, Fung E, Bose S, Popp A, Böser P, Memmott J, Kutskova YA, Miller R, Tarcsa E, Klein C, Veldman GM, Mueller BK, Cui YF. Huang L, et al. Among authors: klein c. Neurobiol Dis. 2021 Nov;159:105492. doi: 10.1016/j.nbd.2021.105492. Epub 2021 Aug 31. Neurobiol Dis. 2021. PMID: 34478849 Free article.
Peptide Boronic Acids by Late-Stage Hydroboration on the Solid Phase.
Werner M, Brinkhofer J, Hammermüller L, Heim T, Pham TL, Huber J, Klein C, Thomas F. Werner M, et al. Among authors: klein c. Adv Sci (Weinh). 2024 May 29:e2400640. doi: 10.1002/advs.202400640. Online ahead of print. Adv Sci (Weinh). 2024. PMID: 38810019
3,912 results