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A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.
Lu S, Kanekura K, Hara T, Mahadevan J, Spears LD, Oslowski CM, Martinez R, Yamazaki-Inoue M, Toyoda M, Neilson A, Blanner P, Brown CM, Semenkovich CF, Marshall BA, Hershey T, Umezawa A, Greer PA, Urano F. Lu S, et al. Among authors: semenkovich cf. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5292-301. doi: 10.1073/pnas.1421055111. Epub 2014 Nov 24. Proc Natl Acad Sci U S A. 2014. PMID: 25422446 Free PMC article.
Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration.
Spears LD, Adak S, Dong G, Wei X, Spyropoulos G, Zhang Q, Yin L, Feng C, Hu D, Lodhi IJ, Hsu FF, Rajagopal R, Noguchi KK, Halabi CM, Brier L, Bice AR, Lananna BV, Musiek ES, Avraham O, Cavalli V, Holth JK, Holtzman DM, Wozniak DF, Culver JP, Semenkovich CF. Spears LD, et al. Among authors: semenkovich cf. J Lipid Res. 2021;62:100079. doi: 10.1016/j.jlr.2021.100079. Epub 2021 Apr 21. J Lipid Res. 2021. PMID: 33894211 Free PMC article.
FASN-dependent de novo lipogenesis is required for brain development.
Gonzalez-Bohorquez D, Gallego López IM, Jaeger BN, Pfammatter S, Bowers M, Semenkovich CF, Jessberger S. Gonzalez-Bohorquez D, et al. Among authors: semenkovich cf. Proc Natl Acad Sci U S A. 2022 Jan 11;119(2):e2112040119. doi: 10.1073/pnas.2112040119. Proc Natl Acad Sci U S A. 2022. PMID: 34996870 Free PMC article.
Parent-of-origin effects propagate through networks to shape metabolic traits.
Macias-Velasco JF, St Pierre CL, Wayhart JP, Yin L, Spears L, Miranda MA, Carson C, Funai K, Cheverud JM, Semenkovich CF, Lawson HA. Macias-Velasco JF, et al. Among authors: semenkovich cf. Elife. 2022 Mar 31;11:e72989. doi: 10.7554/eLife.72989. Elife. 2022. PMID: 35356864 Free PMC article.
Palmitoylation couples insulin hypersecretion with β cell failure in diabetes.
Dong G, Adak S, Spyropoulos G, Zhang Q, Feng C, Yin L, Speck SL, Shyr Z, Morikawa S, Kitamura RA, Kathayat RS, Dickinson BC, Ng XW, Piston DW, Urano F, Remedi MS, Wei X, Semenkovich CF. Dong G, et al. Among authors: semenkovich cf. Cell Metab. 2023 Feb 7;35(2):332-344.e7. doi: 10.1016/j.cmet.2022.12.012. Epub 2023 Jan 11. Cell Metab. 2023. PMID: 36634673 Free PMC article.
198 results