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Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study.
Mackman RL, Sangi M, Sperandio D, Parrish JP, Eisenberg E, Perron M, Hui H, Zhang L, Siegel D, Yang H, Saunders O, Boojamra C, Lee G, Samuel D, Babaoglu K, Carey A, Gilbert BE, Piedra PA, Strickley R, Iwata Q, Hayes J, Stray K, Kinkade A, Theodore D, Jordan R, Desai M, Cihlar T. Mackman RL, et al. Among authors: kinkade a. J Med Chem. 2015 Feb 26;58(4):1630-43. doi: 10.1021/jm5017768. Epub 2015 Jan 27. J Med Chem. 2015. PMID: 25574686 Clinical Trial.
Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues.
Wang G, Wan J, Hu Y, Wu X, Prhavc M, Dyatkina N, Rajwanshi VK, Smith DB, Jekle A, Kinkade A, Symons JA, Jin Z, Deval J, Zhang Q, Tam Y, Chanda S, Blatt L, Beigelman L. Wang G, et al. Among authors: kinkade a. J Med Chem. 2016 May 26;59(10):4611-24. doi: 10.1021/acs.jmedchem.5b01933. Epub 2016 Apr 27. J Med Chem. 2016. PMID: 27120583
The DARC conspiracy--virus invasion tactics.
Kinkade A, Ware CF. Kinkade A, et al. Trends Immunol. 2006 Aug;27(8):362-7. doi: 10.1016/j.it.2006.06.004. Epub 2006 Jun 27. Trends Immunol. 2006. PMID: 16807107
Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.
Jekle A, Thatikonda SK, Jaisinghani R, Ren S, Kinkade A, Stevens SK, Stoycheva A, Rajwanshi VK, Williams C, Deval J, Mukherjee S, Zhang Q, Chanda S, Smith DB, Blatt LM, Symons JA, Gonzalvez F, Beigelman L. Jekle A, et al. Among authors: kinkade a. Int J Mol Sci. 2023 Nov 13;24(22):16274. doi: 10.3390/ijms242216274. Int J Mol Sci. 2023. PMID: 38003463 Free PMC article.
Reduced fixed dose tocilizumab 400 mg IV compared to weight-based dosing in critically ill patients with COVID-19: A before-after cohort study.
Stukas S, Goshua G, Kinkade A, Grey R, Mah G, Biggs CM, Jamal S, Thiara S, Lau TTY, Piszczek J, Partovi N, Sweet DD, Lee AYY, Wellington CL, Sekhon MS, Chen LYC. Stukas S, et al. Among authors: kinkade a. Lancet Reg Health Am. 2022 Jul;11:100228. doi: 10.1016/j.lana.2022.100228. Epub 2022 Mar 23. Lancet Reg Health Am. 2022. PMID: 35345649 Free PMC article.
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