Dean RA - Search Results

1

The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans.

May PC, Willis BA, Lowe SL, Dean RA, Monk SA, Cocke PJ, Audia JE, Boggs LN, Borders AR, Brier RA, Calligaro DO, Day TA, Ereshefsky L, Erickson JA, Gevorkyan H, Gonzales CR, James DE, Jhee SS, Komjathy SF, Li L, Lindstrom TD, Mathes BM, Martényi F, Sheehan SM, Stout SL, Timm DE, Vaught GM, Watson BM, Winneroski LL, Yang Z, Mergott DJ. May PC, et al. Among authors: dean ra. J Neurosci. 2015 Jan 21;35(3):1199-210. doi: 10.1523/JNEUROSCI.4129-14.2015. J Neurosci. 2015. PMID: 25609634 Free PMC article. Clinical Trial.

2

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers.

Siemers E, Skinner M, Dean RA, Gonzales C, Satterwhite J, Farlow M, Ness D, May PC. Siemers E, et al. Among authors: dean ra. Clin Neuropharmacol. 2005 May-Jun;28(3):126-32. doi: 10.1097/01.wnf.0000167360.27670.29. Clin Neuropharmacol. 2005. PMID: 15965311 Clinical Trial.

3

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.

Siemers ER, Quinn JF, Kaye J, Farlow MR, Porsteinsson A, Tariot P, Zoulnouni P, Galvin JE, Holtzman DM, Knopman DS, Satterwhite J, Gonzales C, Dean RA, May PC. Siemers ER, et al. Among authors: dean ra. Neurology. 2006 Feb 28;66(4):602-4. doi: 10.1212/01.WNL.0000198762.41312.E1. Neurology. 2006. PMID: 16505324 Clinical Trial.

4

New pathways in drug discovery for Alzheimer's disease.

Siemers ER, Dean RA, Demattos R, May PC. Siemers ER, et al. Among authors: dean ra. Curr Neurol Neurosci Rep. 2006 Sep;6(5):372-8. doi: 10.1007/s11910-996-0017-8. Curr Neurol Neurosci Rep. 2006. PMID: 16928346 Review.

5

Identifying pharmacodynamic protein markers of centrally active drugs in humans: a pilot study in a novel clinical model.

Patil ST, Higgs RE, Brandt JE, Knierman MD, Gelfanova V, Butler JP, Downing AM, Dorocke J, Dean RA, Potter WZ, Michelson D, Pan AX, Jhee SS, Hale JE. Patil ST, et al. Among authors: dean ra. J Proteome Res. 2007 Mar;6(3):955-66. doi: 10.1021/pr0603710. Epub 2007 Jan 23. J Proteome Res. 2007. PMID: 17243662

6

Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase.

Siemers ER, Dean RA, Friedrich S, Ferguson-Sells L, Gonzales C, Farlow MR, May PC. Siemers ER, et al. Among authors: dean ra. Clin Neuropharmacol. 2007 Nov-Dec;30(6):317-25. doi: 10.1097/WNF.0b013e31805b7660. Clin Neuropharmacol. 2007. PMID: 18090456 Clinical Trial.

7

Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease.

Henley DB, May PC, Dean RA, Siemers ER. Henley DB, et al. Among authors: dean ra. Expert Opin Pharmacother. 2009 Jul;10(10):1657-64. doi: 10.1517/14656560903044982. Expert Opin Pharmacother. 2009. PMID: 19527190 Review.

8

Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease.

Siemers ER, Friedrich S, Dean RA, Gonzales CR, Farlow MR, Paul SM, Demattos RB. Siemers ER, et al. Among authors: dean ra. Clin Neuropharmacol. 2010 Mar-Apr;33(2):67-73. doi: 10.1097/WNF.0b013e3181cb577a. Clin Neuropharmacol. 2010. PMID: 20375655 Clinical Trial.

9

Role of biochemical Alzheimer's disease biomarkers as end points in clinical trials.

Siemers E, DeMattos RB, May PC, Dean RA. Siemers E, et al. Among authors: dean ra. Biomark Med. 2010 Feb;4(1):81-9. doi: 10.2217/bmm.09.85. Biomark Med. 2010. PMID: 20387304 Review.

10

Validation of ELISA methods for quantification of total tau and phosporylated-tau181 in human cerebrospinal fluid with measurement in specimens from two Alzheimer's disease studies.

Lachno DR, Romeo MJ, Siemers ER, Vanderstichele H, Coart E, Konrad RJ, Zajac JJ, Talbot JA, Jensen HF, Sethuraman G, Demattos RB, May PC, Dean RA. Lachno DR, et al. Among authors: dean ra. J Alzheimers Dis. 2011;26(3):531-41. doi: 10.3233/JAD-2011-110296. J Alzheimers Dis. 2011. PMID: 21694458

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