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Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.
Bioorg Med Chem Lett. 2015 Mar 1;25(5):1117-23. doi: 10.1016/j.bmcl.2014.12.089. Epub 2015 Jan 13.
Bioorg Med Chem Lett. 2015.
PMID: 25630225
Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase.
Lacbay CM, Mancuso J, Lin YS, Bennett N, Götte M, Tsantrizos YS.
Lacbay CM, et al.
J Med Chem. 2014 Sep 11;57(17):7435-49. doi: 10.1021/jm501010f. Epub 2014 Aug 29.
J Med Chem. 2014.
PMID: 25144111
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Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.
Park J, Leung CY, Matralis AN, Lacbay CM, Tsakos M, Fernandez De Troconiz G, Berghuis AM, Tsantrizos YS.
Park J, et al. Among authors: lacbay cm.
J Med Chem. 2017 Mar 9;60(5):2119-2134. doi: 10.1021/acs.jmedchem.6b01888. Epub 2017 Feb 28.
J Med Chem. 2017.
PMID: 28208018
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Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.
Lacbay CM, Waller DD, Park J, Gómez Palou M, Vincent F, Huang XF, Ta V, Berghuis AM, Sebag M, Tsantrizos YS.
Lacbay CM, et al.
J Med Chem. 2018 Aug 9;61(15):6904-6917. doi: 10.1021/acs.jmedchem.8b00886. Epub 2018 Jul 25.
J Med Chem. 2018.
PMID: 30016091
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Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase.
Lee HF, Lacbay CM, Boutin R, Matralis AN, Park J, Waller DD, Guan TL, Sebag M, Tsantrizos YS.
Lee HF, et al. Among authors: lacbay cm.
J Med Chem. 2022 Feb 10;65(3):2471-2496. doi: 10.1021/acs.jmedchem.1c01913. Epub 2022 Jan 25.
J Med Chem. 2022.
PMID: 35077178
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Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively "Freeze" the pre-translocated complex during the polymerization catalytic cycle.
Lacbay CM, Menni M, Bernatchez JA, Götte M, Tsantrizos YS.
Lacbay CM, et al.
Bioorg Med Chem. 2018 May 1;26(8):1713-1726. doi: 10.1016/j.bmc.2018.02.017. Epub 2018 Feb 14.
Bioorg Med Chem. 2018.
PMID: 29478802
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Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500).
Black WC, Abdoli A, An X, Auger A, Beaulieu P, Bernatchez M, Caron C, Chefson A, Crane S, Diallo M, Dorich S, Fader LD, Ferraro GB, Fournier S, Gao Q, Ginzburg Y, Hamel M, Han Y, Jones P, Lanoix S, Lacbay CM, Leclaire ME, Levy M, Mamane Y, Mulani A, Papp R, Pellerin C, Picard A, Skeldon A, Skorey K, Stocco R, St-Onge M, Truchon JF, Truong VL, Zimmermann M, Zinda M, Roulston A.
Black WC, et al. Among authors: lacbay cm.
J Med Chem. 2024 Feb 22;67(4):2349-2368. doi: 10.1021/acs.jmedchem.3c01917. Epub 2024 Feb 1.
J Med Chem. 2024.
PMID: 38299539
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