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Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against ebola virus and marburg virus: results of two single-ascending-dose studies.
Heald AE, Iversen PL, Saoud JB, Sazani P, Charleston JS, Axtelle T, Wong M, Smith WB, Vutikullird A, Kaye E. Heald AE, et al. Among authors: iversen pl. Antimicrob Agents Chemother. 2014 Nov;58(11):6639-47. doi: 10.1128/AAC.03442-14. Epub 2014 Aug 25. Antimicrob Agents Chemother. 2014. PMID: 25155593 Free PMC article. Clinical Trial.
AVI-7288 for Marburg Virus in Nonhuman Primates and Humans.
Heald AE, Charleston JS, Iversen PL, Warren TK, Saoud JB, Al-Ibrahim M, Wells J, Warfield KL, Swenson DL, Welch LS, Sazani P, Wong M, Berry D, Kaye EM, Bavari S. Heald AE, et al. Among authors: iversen pl. N Engl J Med. 2015 Jul 23;373(4):339-48. doi: 10.1056/NEJMoa1410345. N Engl J Med. 2015. PMID: 26200980 Free article. Clinical Trial.
Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques.
Warren TK, Whitehouse CA, Wells J, Welch L, Charleston JS, Heald A, Nichols DK, Mattix ME, Palacios G, Kugleman JR, Iversen PL, Bavari S. Warren TK, et al. Among authors: iversen pl. PLoS Negl Trop Dis. 2016 Feb 22;10(2):e0004456. doi: 10.1371/journal.pntd.0004456. eCollection 2016 Feb. PLoS Negl Trop Dis. 2016. PMID: 26901785 Free PMC article.
Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus.
Warren TK, Kane CD, Wells J, Stuthman KS, Van Tongeren SA, Garza NL, Donnelly G, Steffens J, Gomba L, Weidner JM, Norris S, Zeng X, Bannister R, Cihlar T, Bavari S, Porter DP, Iversen PL. Warren TK, et al. Among authors: iversen pl. Sci Rep. 2021 Sep 30;11(1):19458. doi: 10.1038/s41598-021-98971-0. Sci Rep. 2021. PMID: 34593911 Free PMC article.
209 results