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Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways.
Herrmann US, Sonati T, Falsig J, Reimann RR, Dametto P, O'Connor T, Li B, Lau A, Hornemann S, Sorce S, Wagner U, Sanoudou D, Aguzzi A. Herrmann US, et al. Among authors: lau a. PLoS Pathog. 2015 Feb 24;11(2):e1004662. doi: 10.1371/journal.ppat.1004662. eCollection 2015 Feb. PLoS Pathog. 2015. PMID: 25710374 Free PMC article.
Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.
Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KW, Schmitt-Ulms G, Dearmond SJ, McKenzie D, Hood L, Carlson GA. Westaway D, et al. Among authors: lau a. PLoS Pathog. 2011 Nov;7(11):e1002391. doi: 10.1371/journal.ppat.1002391. Epub 2011 Nov 17. PLoS Pathog. 2011. PMID: 22114562 Free PMC article.
Prion disease tempo determined by host-dependent substrate reduction.
Mays CE, Kim C, Haldiman T, van der Merwe J, Lau A, Yang J, Grams J, Di Bari MA, Nonno R, Telling GC, Kong Q, Langeveld J, McKenzie D, Westaway D, Safar JG. Mays CE, et al. Among authors: lau a. J Clin Invest. 2014 Feb;124(2):847-58. doi: 10.1172/JCI72241. Epub 2014 Jan 16. J Clin Invest. 2014. PMID: 24430187 Free PMC article.
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation.
Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, Balachandran A, Schmitt-Ulms G, Safar JG, Millhauser GL, Westaway D. Lau A, et al. EMBO Mol Med. 2015 Mar;7(3):339-56. doi: 10.15252/emmm.201404588. EMBO Mol Med. 2015. PMID: 25661904 Free PMC article.
Deep learning for the PSIPRED Protein Analysis Workbench.
Buchan DWA, Moffat L, Lau A, Kandathil SM, Jones DT. Buchan DWA, et al. Among authors: lau a. Nucleic Acids Res. 2024 May 15:gkae328. doi: 10.1093/nar/gkae328. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38747351
Bulevirtide monotherapy in patients with chronic HDV: Efficacy and safety results through week 96 from a phase 3 randomized trial.
Wedemeyer H, Aleman S, Brunetto M, Blank A, Andreone P, Bogomolov P, Chulanov V, Mamonova N, Geyvandova N, Morozov V, Sagalova O, Stepanova T, Berger A, Ciesek S, Manuilov D, Mercier RC, Da BL, Chee GM, Li M, Flaherty JF, Lau AH, Osinusi A, Schulze Zur Wiesch J, Cornberg M, Zeuzem S, Lampertico P. Wedemeyer H, et al. Among authors: lau ah. J Hepatol. 2024 May 9:S0168-8278(24)00333-7. doi: 10.1016/j.jhep.2024.05.001. Online ahead of print. J Hepatol. 2024. PMID: 38734383 Free article.
2,180 results