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Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways.
Herrmann US, Sonati T, Falsig J, Reimann RR, Dametto P, O'Connor T, Li B, Lau A, Hornemann S, Sorce S, Wagner U, Sanoudou D, Aguzzi A. Herrmann US, et al. Among authors: sonati t. PLoS Pathog. 2015 Feb 24;11(2):e1004662. doi: 10.1371/journal.ppat.1004662. eCollection 2015 Feb. PLoS Pathog. 2015. PMID: 25710374 Free PMC article.
The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.
Sonati T, Reimann RR, Falsig J, Baral PK, O'Connor T, Hornemann S, Yaganoglu S, Li B, Herrmann US, Wieland B, Swayampakula M, Rahman MH, Das D, Kav N, Riek R, Liberski PP, James MN, Aguzzi A. Sonati T, et al. Nature. 2013 Sep 5;501(7465):102-6. doi: 10.1038/nature12402. Epub 2013 Jul 31. Nature. 2013. PMID: 23903654 Free article.
Differential Toxicity of Antibodies to the Prion Protein.
Reimann RR, Sonati T, Hornemann S, Herrmann US, Arand M, Hawke S, Aguzzi A. Reimann RR, et al. Among authors: sonati t. PLoS Pathog. 2016 Jan 28;12(1):e1005401. doi: 10.1371/journal.ppat.1005401. eCollection 2016 Jan. PLoS Pathog. 2016. PMID: 26821311 Free PMC article.
Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates.
Margalith I, Suter C, Ballmer B, Schwarz P, Tiberi C, Sonati T, Falsig J, Nyström S, Hammarström P, Aslund A, Nilsson KP, Yam A, Whitters E, Hornemann S, Aguzzi A. Margalith I, et al. Among authors: sonati t. J Biol Chem. 2012 Jun 1;287(23):18872-87. doi: 10.1074/jbc.M112.355958. Epub 2012 Apr 6. J Biol Chem. 2012. PMID: 22493452 Free PMC article.
The Priority position paper: Protecting Europe's food chain from prions.
Requena JR, Kristensson K, Korth C, Zurzolo C, Simmons M, Aguilar-Calvo P, Aguzzi A, Andreoletti O, Benestad SL, Böhm R, Brown K, Calgua B, Del Río JA, Espinosa JC, Girones R, Godsave S, Hoelzle LE, Knittler MR, Kuhn F, Legname G, Laeven P, Mabbott N, Mitrova E, Müller-Schiffmann A, Nuvolone M, Peters PJ, Raeber A, Roth K, Schmitz M, Schroeder B, Sonati T, Stitz L, Taraboulos A, Torres JM, Yan ZX, Zerr I. Requena JR, et al. Among authors: sonati t. Prion. 2016 May 3;10(3):165-81. doi: 10.1080/19336896.2016.1175801. Prion. 2016. PMID: 27220820 Free PMC article.