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Targeting repulsive guidance molecule A to promote regeneration and neuroprotection in multiple sclerosis.
Demicheva E, Cui YF, Bardwell P, Barghorn S, Kron M, Meyer AH, Schmidt M, Gerlach B, Leddy M, Barlow E, O'Connor E, Choi CH, Huang L, Veldman GM, Rus H, Shabanzadeh AP, Tassew NG, Monnier PP, Müller T, Calabresi PA, Schoemaker H, Mueller BK. Demicheva E, et al. Among authors: huang l. Cell Rep. 2015 Mar 24;10(11):1887-98. doi: 10.1016/j.celrep.2015.02.048. Cell Rep. 2015. PMID: 25801027 Free article.
Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models.
Huang L, Fung E, Bose S, Popp A, Böser P, Memmott J, Kutskova YA, Miller R, Tarcsa E, Klein C, Veldman GM, Mueller BK, Cui YF. Huang L, et al. Neurobiol Dis. 2021 Nov;159:105492. doi: 10.1016/j.nbd.2021.105492. Epub 2021 Aug 31. Neurobiol Dis. 2021. PMID: 34478849 Free article.
Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates.
Jacobson PB, Goody R, Lawrence M, Mueller BK, Zhang X, Hooker BA, Pfleeger K, Ziemann A, Locke C, Barraud Q, Droescher M, Bernhard J, Popp A, Boeser P, Huang L, Mollon J, Mordashova Y, Cui YF, Savaryn JP, Grinnell C, Dreher I, Gold M, Courtine G, Mothe A, Tator CH, Guest JD. Jacobson PB, et al. Among authors: huang l. Neurobiol Dis. 2021 Jul;155:105385. doi: 10.1016/j.nbd.2021.105385. Epub 2021 May 12. Neurobiol Dis. 2021. PMID: 33991647 Free article.
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