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Page 1
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.
Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD. Kwon YD, et al. Among authors: arthos j. Nat Struct Mol Biol. 2015 Jul;22(7):522-31. doi: 10.1038/nsmb.3051. Epub 2015 Jun 22. Nat Struct Mol Biol. 2015. PMID: 26098315 Free PMC article.
Crystal structure of an HIV-binding recombinant fragment of human CD4.
Ryu SE, Kwong PD, Truneh A, Porter TG, Arthos J, Rosenberg M, Dai XP, Xuong NH, Axel R, Sweet RW, et al. Ryu SE, et al. Among authors: arthos j. Nature. 1990 Nov 29;348(6300):419-26. doi: 10.1038/348419a0. Nature. 1990. PMID: 2247146 Free PMC article.
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.
Kwong PD, Doyle ML, Casper DJ, Cicala C, Leavitt SA, Majeed S, Steenbeke TD, Venturi M, Chaiken I, Fung M, Katinger H, Parren PW, Robinson J, Van Ryk D, Wang L, Burton DR, Freire E, Wyatt R, Sodroski J, Hendrickson WA, Arthos J. Kwong PD, et al. Among authors: arthos j. Nature. 2002 Dec 12;420(6916):678-82. doi: 10.1038/nature01188. Nature. 2002. PMID: 12478295
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD. Zhou T, et al. Among authors: arthos j. Nature. 2007 Feb 15;445(7129):732-7. doi: 10.1038/nature05580. Nature. 2007. PMID: 17301785 Free PMC article.
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Chen L, Kwon YD, Zhou T, Wu X, O'Dell S, Cavacini L, Hessell AJ, Pancera M, Tang M, Xu L, Yang ZY, Zhang MY, Arthos J, Burton DR, Dimitrov DS, Nabel GJ, Posner MR, Sodroski J, Wyatt R, Mascola JR, Kwong PD. Chen L, et al. Among authors: arthos j. Science. 2009 Nov 20;326(5956):1123-7. doi: 10.1126/science.1175868. Science. 2009. PMID: 19965434 Free PMC article.
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Kwon YD, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD. McLellan JS, et al. Among authors: arthos j. Nature. 2011 Nov 23;480(7377):336-43. doi: 10.1038/nature10696. Nature. 2011. PMID: 22113616 Free PMC article.
Virion attachment and entry: HIV gp120 Env biotinylation, gp120 Env, or integrin ligand-binding assay.
Cicala C, Arthos J. Cicala C, et al. Among authors: arthos j. Methods Mol Biol. 2014;1087:3-12. doi: 10.1007/978-1-62703-670-2_1. Methods Mol Biol. 2014. PMID: 24158809
In addition it has recently been demonstrated that HIV-1 gp120 binds to and signals through integrin alpha4beta7, the gut-homing receptor (Arthos et al., Nat Immunol 9(3):301-309, 2008). Integrin alpha4beta7 is not an entry receptor for HIV-1, although it can facilitate vi …
In addition it has recently been demonstrated that HIV-1 gp120 binds to and signals through integrin alpha4beta7, the gut-homing receptor ( …
135 results