van Unen J - Search Results

1

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.

Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW Jr, Yin T, Wu Y, Huveneers S, van Buul JD. Timmerman I, et al. Among authors: van buul jd, van rijssel j, van unen j. J Cell Sci. 2015 Aug 15;128(16):3041-54. doi: 10.1242/jcs.168674. Epub 2015 Jun 26. J Cell Sci. 2015. PMID: 26116572

2

The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signaling.

van Unen J, Botman D, Yin T, Wu YI, Hink MA, Gadella TWJ Jr, Postma M, Goedhart J. van Unen J, et al. BMC Cell Biol. 2018 Jun 7;19(1):6. doi: 10.1186/s12860-018-0155-2. BMC Cell Biol. 2018. PMID: 29879899 Free PMC article.

3

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.

Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW Jr, Yin T, Wu Y, Huveneers S, van Buul JD. Timmerman I, et al. Among authors: van buul jd, van rijssel j, van unen j. J Cell Sci. 2015 Sep 15;128(18):3514. doi: 10.1242/jcs.179424. J Cell Sci. 2015. PMID: 26374854 Free PMC article. No abstract available.

4

F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling.

Heemskerk N, Schimmel L, Oort C, van Rijssel J, Yin T, Ma B, van Unen J, Pitter B, Huveneers S, Goedhart J, Wu Y, Montanez E, Woodfin A, van Buul JD. Heemskerk N, et al. Among authors: van unen j. Nat Commun. 2016 Jan 27;7:10493. doi: 10.1038/ncomms10493. Nat Commun. 2016. PMID: 26814335 Free PMC article.

5

Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq.

van Unen J, Yin T, Wu YI, Mastop M, Gadella TW Jr, Goedhart J. van Unen J, et al. Sci Rep. 2016 Nov 11;6:36825. doi: 10.1038/srep36825. Sci Rep. 2016. PMID: 27833100 Free PMC article.

6

Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells.

Goedhart J, van Unen J. Goedhart J, et al. Among authors: van unen j. Small GTPases. 2019 May;10(3):178-186. doi: 10.1080/21541248.2017.1302551. Epub 2017 May 19. Small GTPases. 2019. PMID: 28521592 Free PMC article. Review.

7

Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location.

Goedhart J, van Unen J, Adjobo-Hermans MJ, Gadella TW Jr. Goedhart J, et al. Among authors: van unen j. Sci Rep. 2013;3:2284. doi: 10.1038/srep02284. Sci Rep. 2013. PMID: 23884432 Free PMC article.

8

Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization.

van Unen J, Reinhard NR, Yin T, Wu YI, Postma M, Gadella TW, Goedhart J. van Unen J, et al. Sci Rep. 2015 Oct 5;5:14693. doi: 10.1038/srep14693. Sci Rep. 2015. PMID: 26435194 Free PMC article.

9

Quantitative Single-Cell Analysis of Signaling Pathways Activated Immediately Downstream of Histamine Receptor Subtypes.

van Unen J, Rashidfarrokhi A, Hoogendoorn E, Postma M, Gadella TW Jr, Goedhart J. van Unen J, et al. Mol Pharmacol. 2016 Sep;90(3):162-76. doi: 10.1124/mol.116.104505. Epub 2016 Jun 29. Mol Pharmacol. 2016. PMID: 27358232

10

A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells.

van Unen J, Stumpf AD, Schmid B, Reinhard NR, Hordijk PL, Hoffmann C, Gadella TW Jr, Goedhart J. van Unen J, et al. PLoS One. 2016 Jan 22;11(1):e0146789. doi: 10.1371/journal.pone.0146789. eCollection 2016. PLoS One. 2016. PMID: 26799488 Free PMC article.

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