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AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia.
Blood. 2015 Sep 3;126(10):1193-202. doi: 10.1182/blood-2014-12-618900. Epub 2015 Jun 26.
Blood. 2015.
PMID: 26116659
Free PMC article.
A single nucleotide polymorphism genotyping platform for the authentication of patient derived xenografts.
El-Hoss J, Jing D, Evans K, Toscan C, Xie J, Lee H, Taylor RA, Lawrence MG, Risbridger GP, MacKenzie KL, Sutton R, Lock RB.
El-Hoss J, et al.
Oncotarget. 2016 Sep 13;7(37):60475-60490. doi: 10.18632/oncotarget.11125.
Oncotarget. 2016.
PMID: 27528024
Free PMC article.
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High-throughput screening of human leukemia xenografts to identify dexamethasone sensitizers.
Toscan CE, Failes T, Arndt GM, Lock RB.
Toscan CE, et al.
J Biomol Screen. 2014 Dec;19(10):1391-401. doi: 10.1177/1087057114546550. Epub 2014 Aug 7.
J Biomol Screen. 2014.
PMID: 25104793
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Thioimidazoline based compounds reverse glucocorticoid resistance in human acute lymphoblastic leukemia xenografts.
Toscan CE, Rahimi M, Bhadbhade M, Pickford R, McAlpine SR, Lock RB.
Toscan CE, et al.
Org Biomol Chem. 2015 Jun 14;13(22):6299-312. doi: 10.1039/c5ob00779h.
Org Biomol Chem. 2015.
PMID: 25967739
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Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia.
Jing D, Huang Y, Liu X, Sia KCS, Zhang JC, Tai X, Wang M, Toscan CE, McCalmont H, Evans K, Mayoh C, Poulos RC, Span M, Mi J, Zhang C, Wong JWH, Beck D, Pimanda JE, Lock RB.
Jing D, et al. Among authors: toscan ce.
Cancer Cell. 2018 Dec 10;34(6):906-921.e8. doi: 10.1016/j.ccell.2018.11.002.
Cancer Cell. 2018.
PMID: 30537513
Free article.
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OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL.
Evans K, Duan J, Pritchard T, Jones CD, McDermott L, Gu Z, Toscan CE, El-Zein N, Mayoh C, Erickson SW, Guo Y, Meng F, Jung D, Rathi KS, Roberts KG, Mullighan CG, Shia CS, Pearce T, Teicher BA, Smith MA, Lock RB.
Evans K, et al. Among authors: toscan ce.
Clin Cancer Res. 2019 Jul 15;25(14):4493-4503. doi: 10.1158/1078-0432.CCR-19-0551. Epub 2019 Apr 23.
Clin Cancer Res. 2019.
PMID: 31015346
Free PMC article.
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Reversal of glucocorticoid resistance in paediatric acute lymphoblastic leukaemia is dependent on restoring BIM expression.
Toscan CE, Jing D, Mayoh C, Lock RB.
Toscan CE, et al.
Br J Cancer. 2020 Jun;122(12):1769-1781. doi: 10.1038/s41416-020-0824-8. Epub 2020 Apr 3.
Br J Cancer. 2020.
PMID: 32242100
Free PMC article.
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