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A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer.
Dijkgraaf EM, Santegoets SJ, Reyners AK, Goedemans R, Wouters MC, Kenter GG, van Erkel AR, van Poelgeest MI, Nijman HW, van der Hoeven JJ, Welters MJ, van der Burg SH, Kroep JR. Dijkgraaf EM, et al. Among authors: nijman hw. Ann Oncol. 2015 Oct;26(10):2141-9. doi: 10.1093/annonc/mdv309. Epub 2015 Jul 27. Ann Oncol. 2015. PMID: 26216383 Free article. Clinical Trial.
p53, a potential target for tumor-directed T cells.
Nijman HW, Van der Burg SH, Vierboom MP, Houbiers JG, Kast WM, Melief CJ. Nijman HW, et al. Immunol Lett. 1994 May;40(2):171-8. doi: 10.1016/0165-2478(94)90189-9. Immunol Lett. 1994. PMID: 8088874
Interleukin-6 receptor and its ligand interleukin-6 are opposite markers for survival and infiltration with mature myeloid cells in ovarian cancer.
Wouters M, Dijkgraaf EM, Kuijjer ML, Jordanova ES, Hollema H, Welters M, van der Hoeven J, Daemen T, Kroep JR, Nijman HW, van der Burg SH. Wouters M, et al. Among authors: nijman hw. Oncoimmunology. 2015 Jan 7;3(12):e962397. doi: 10.4161/21624011.2014.962397. eCollection 2014 Dec. Oncoimmunology. 2015. PMID: 25964862 Free PMC article.
197 results