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DYRK1B regulates Hedgehog-induced microtubule acetylation.
Singh R, Holz PS, Roth K, Hupfer A, Meissner W, Müller R, Buchholz M, Gress TM, Elsässer HP, Jacob R, Lauth M. Singh R, et al. Cell Mol Life Sci. 2019 Jan;76(1):193-207. doi: 10.1007/s00018-018-2942-5. Epub 2018 Oct 13. Cell Mol Life Sci. 2019. PMID: 30317528 Free PMC article.
Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors.
Didiasova M, Singh R, Wilhelm J, Kwapiszewska G, Wujak L, Zakrzewicz D, Schaefer L, Markart P, Seeger W, Lauth M, Wygrecka M. Didiasova M, et al. Among authors: singh r. FASEB J. 2017 May;31(5):1916-1928. doi: 10.1096/fj.201600892RR. Epub 2017 Feb 1. FASEB J. 2017. PMID: 28148565
Because GLI transcription factors are not only crucial for Hh-mediated changes but are also required as mediators of TGF-beta signaling, our findings suggest that pirfenidone exerts its clinically beneficial effects through dual Hh/TGF-beta inhibition by targeting the GLI2 protei …
Because GLI transcription factors are not only crucial for Hh-mediated changes but are also required as mediators of TGF-beta signaling, our …
The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes.
Luu M, Pautz S, Kohl V, Singh R, Romero R, Lucas S, Hofmann J, Raifer H, Vachharajani N, Carrascosa LC, Lamp B, Nist A, Stiewe T, Shaul Y, Adhikary T, Zaiss MM, Lauth M, Steinhoff U, Visekruna A. Luu M, et al. Among authors: singh r. Nat Commun. 2019 Feb 15;10(1):760. doi: 10.1038/s41467-019-08711-2. Nat Commun. 2019. PMID: 30770822 Free PMC article.
Faricimab for neovascular age-related macular degeneration and diabetic macular edema: from preclinical studies to phase 3 outcomes.
Agostini H, Abreu F, Baumal CR, Chang DS, G Csaky K, Demetriades AM, Kodjikian L, Lim JI, Margaron P, Monés JM, Peto T, Ricci F, Rüth M, Singh RP, Stoilov I, Swaminathan B, Willis JR, Westenskow PD. Agostini H, et al. Among authors: singh rp. Graefes Arch Clin Exp Ophthalmol. 2024 Jun 7. doi: 10.1007/s00417-024-06531-9. Online ahead of print. Graefes Arch Clin Exp Ophthalmol. 2024. PMID: 38847896 Review.
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