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Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study.
Jones RP, Sutton P, Greensmith RM, Santoyo-Castelazo A, Carr DF, Jenkins R, Rowe C, Hamlett J, Park BK, Terlizzo M, O'Grady E, Ghaneh P, Fenwick SW, Malik HZ, Poston GJ, Kitteringham NR. Jones RP, et al. Among authors: kitteringham nr. Cancer Chemother Pharmacol. 2013 Aug;72(2):359-68. doi: 10.1007/s00280-013-2199-5. Epub 2013 Jun 12. Cancer Chemother Pharmacol. 2013. PMID: 23756919 Clinical Trial.
Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile.
Heslop JA, Rowe C, Walsh J, Sison-Young R, Jenkins R, Kamalian L, Kia R, Hay D, Jones RP, Malik HZ, Fenwick S, Chadwick AE, Mills J, Kitteringham NR, Goldring CE, Kevin Park B. Heslop JA, et al. Arch Toxicol. 2017 Jan;91(1):439-452. doi: 10.1007/s00204-016-1694-y. Epub 2016 Apr 2. Arch Toxicol. 2017. PMID: 27039104 Free PMC article.
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
Evans JP, Winiarski BK, Sutton PA, Jones RP, Ressel L, Duckworth CA, Pritchard DM, Lin ZX, Fretwell VL, Tweedle EM, Costello E, Goldring CE, Copple IM, Park BK, Palmer DH, Kitteringham NR. Evans JP, et al. Among authors: kitteringham nr. Oncotarget. 2018 Jun 5;9(43):27104-27116. doi: 10.18632/oncotarget.25497. eCollection 2018 Jun 5. Oncotarget. 2018. PMID: 29930754 Free PMC article.
157 results