Moeller A - Search Results

1

Anticonvulsant effects of structurally diverse GABA(B) positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model.

Brown JW, Moeller A, Schmidt M, Turner SC, Nimmrich V, Ma J, Rueter LE, van der Kam E, Zhang M. Brown JW, et al. Among authors: moeller a. Neuropharmacology. 2016 Feb;101:358-69. doi: 10.1016/j.neuropharm.2015.10.009. Epub 2015 Oct 22. Neuropharmacology. 2016. PMID: 26471422

2

Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides.

Kling A, Jantos K, Mack H, Hornberger W, Drescher K, Nimmrich V, Relo A, Wicke K, Hutchins CW, Lao Y, Marsh K, Moeller A. Kling A, et al. Among authors: moeller a. J Med Chem. 2017 Aug 24;60(16):7123-7138. doi: 10.1021/acs.jmedchem.7b00731. Epub 2017 Aug 15. J Med Chem. 2017. PMID: 28759231

3

Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability.

Jantos K, Kling A, Mack H, Hornberger W, Moeller A, Nimmrich V, Lao Y, Nijsen M. Jantos K, et al. Among authors: moeller a. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1968-1973. doi: 10.1016/j.bmcl.2019.05.034. Epub 2019 May 18. Bioorg Med Chem Lett. 2019. PMID: 31133534

4

The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo.

Nikkel AL, Martino B, Markosyan S, Brederson JD, Medeiros R, Moeller A, Bitner RS. Nikkel AL, et al. Among authors: moeller a. Neuropharmacology. 2012 Sep;63(4):606-12. doi: 10.1016/j.neuropharm.2012.05.011. Epub 2012 May 18. Neuropharmacology. 2012. PMID: 22613839

5

Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1' Extension.

Kling A, Jantos K, Mack H, Hornberger W, Backfisch G, Lao Y, Nijsen M, Rendenbach-Mueller B, Moeller A. Kling A, et al. Among authors: moeller a. ACS Med Chem Lett. 2018 Feb 4;9(3):221-226. doi: 10.1021/acsmedchemlett.7b00494. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541364 Free PMC article.

6

The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons.

Sinjoanu RC, Kleinschmidt S, Bitner RS, Brioni JD, Moeller A, Ferreira A. Sinjoanu RC, et al. Among authors: moeller a. Neurochem Int. 2008 Sep;53(3-4):79-88. doi: 10.1016/j.neuint.2008.06.003. Epub 2008 Jun 12. Neurochem Int. 2008. PMID: 18590784 Free PMC article.

7

Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.

Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM. Medeiros R, et al. Among authors: moeller a. Am J Pathol. 2012 Aug;181(2):616-25. doi: 10.1016/j.ajpath.2012.04.020. Epub 2012 Jun 9. Am J Pathol. 2012. PMID: 22688056

8

The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking and Relapse with Low Side-Effect Profile.

Vengeliene V, Moeller A, Meinhardt MW, Beardsley PM, Sommer WH, Spanagel R, Bespalov A. Vengeliene V, et al. Among authors: moeller a. Neuropsychopharmacology. 2016 Mar;41(4):979-88. doi: 10.1038/npp.2015.225. Epub 2015 Jul 28. Neuropsychopharmacology. 2016. PMID: 26216521 Free PMC article.

9

Adjusting for the effect of IV contrast on automated CT body composition measures during the portal venous phase.

Moeller AR, Garrett JW, Summers RM, Pickhardt PJ. Moeller AR, et al. Abdom Radiol (NY). 2024 May 15. doi: 10.1007/s00261-024-04376-8. Online ahead of print. Abdom Radiol (NY). 2024. PMID: 38744704

10

Hackflex library preparation enables low-cost metagenomic profiling.

Goldman SL, Sanders JG, Sprockett DD, Landers A, Yan W, Moeller AH. Goldman SL, et al. Among authors: moeller ah. bioRxiv [Preprint]. 2024 Apr 23:2024.04.23.590092. doi: 10.1101/2024.04.23.590092. bioRxiv. 2024. PMID: 38712258 Free PMC article. Preprint.

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