Nijman SMB - Search Results

1

A generic strategy for CRISPR-Cas9-mediated gene tagging.

Lackner DH, Carré A, Guzzardo PM, Banning C, Mangena R, Henley T, Oberndorfer S, Gapp BV, Nijman SMB, Brummelkamp TR, Bürckstümmer T. Lackner DH, et al. Among authors: nijman smb. Nat Commun. 2015 Dec 17;6:10237. doi: 10.1038/ncomms10237. Nat Commun. 2015. PMID: 26674669 Free PMC article.

2

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.

Essletzbichler P, Konopka T, Santoro F, Chen D, Gapp BV, Kralovics R, Brummelkamp TR, Nijman SM, Bürckstümmer T. Essletzbichler P, et al. Genome Res. 2014 Dec;24(12):2059-65. doi: 10.1101/gr.177220.114. Epub 2014 Nov 4. Genome Res. 2014. PMID: 25373145 Free PMC article.

3

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

Brummelkamp TR, Nijman SM, Dirac AM, Bernards R. Brummelkamp TR, et al. Nature. 2003 Aug 14;424(6950):797-801. doi: 10.1038/nature01811. Nature. 2003. PMID: 12917690 Free article.

4

A reversible gene trap collection empowers haploid genetics in human cells.

Bürckstümmer T, Banning C, Hainzl P, Schobesberger R, Kerzendorfer C, Pauler FM, Chen D, Them N, Schischlik F, Rebsamen M, Smida M, Fece de la Cruz F, Lapao A, Liszt M, Eizinger B, Guenzl PM, Blomen VA, Konopka T, Gapp B, Parapatics K, Maier B, Stöckl J, Fischl W, Salic S, Taba Casari MR, Knapp S, Bennett KL, Bock C, Colinge J, Kralovics R, Ammerer G, Casari G, Brummelkamp TR, Superti-Furga G, Nijman SM. Bürckstümmer T, et al. Nat Methods. 2013 Oct;10(10):965-71. doi: 10.1038/nmeth.2609. Epub 2013 Aug 25. Nat Methods. 2013. PMID: 24161985 Free PMC article.

5

Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells.

Forment JV, Herzog M, Coates J, Konopka T, Gapp BV, Nijman SM, Adams DJ, Keane TM, Jackson SP. Forment JV, et al. Nat Chem Biol. 2017 Jan;13(1):12-14. doi: 10.1038/nchembio.2226. Epub 2016 Oct 31. Nat Chem Biol. 2017. PMID: 27820796 Free PMC article.

6

Parallel reverse genetic screening in mutant human cells using transcriptomics.

Gapp BV, Konopka T, Penz T, Dalal V, Bürckstümmer T, Bock C, Nijman SM. Gapp BV, et al. Mol Syst Biol. 2016 Aug 1;12(8):879. doi: 10.15252/msb.20166890. Mol Syst Biol. 2016. PMID: 27482057 Free PMC article.

7

Functional annotation of deubiquitinating enzymes using RNA interference.

Dirac AM, Nijman SM, Brummelkamp TR, Bernards R. Dirac AM, et al. Methods Enzymol. 2005;398:554-67. doi: 10.1016/S0076-6879(05)98045-2. Methods Enzymol. 2005. PMID: 16275358

8

Synthetic lethal vulnerabilities of cancer.

Fece de la Cruz F, Gapp BV, Nijman SM. Fece de la Cruz F, et al. Annu Rev Pharmacol Toxicol. 2015;55:513-31. doi: 10.1146/annurev-pharmtox-010814-124511. Epub 2014 Oct 9. Annu Rev Pharmacol Toxicol. 2015. PMID: 25340932 Review.

9

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing.

Carette JE, Guimaraes CP, Wuethrich I, Blomen VA, Varadarajan M, Sun C, Bell G, Yuan B, Muellner MK, Nijman SM, Ploegh HL, Brummelkamp TR. Carette JE, et al. Nat Biotechnol. 2011 May 29;29(6):542-6. doi: 10.1038/nbt.1857. Nat Biotechnol. 2011. PMID: 21623355 Free PMC article.

10

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R. Nijman SM, et al. Mol Cell. 2005 Feb 4;17(3):331-9. doi: 10.1016/j.molcel.2005.01.008. Mol Cell. 2005. PMID: 15694335 Free article.

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