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PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.
Oncotarget. 2016 Mar 1;7(9):9732-41. doi: 10.18632/oncotarget.6947.
Oncotarget. 2016.
PMID: 26799421
Free PMC article.
High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.
Parplys AC, Seelbach JI, Becker S, Behr M, Wrona A, Jend C, Mansour WY, Joosse SA, Stuerzbecher HW, Pospiech H, Petersen C, Dikomey E, Borgmann K.
Parplys AC, et al. Among authors: seelbach ji.
Cell Cycle. 2015;14(19):3190-202. doi: 10.1080/15384101.2015.1055996.
Cell Cycle. 2015.
PMID: 26317153
Free PMC article.
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