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Page 1
Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors.
Szomolay B, Liu J, Brown PE, Miles JJ, Clement M, Llewellyn-Lacey S, Dolton G, Ekeruche-Makinde J, Lissina A, Schauenburg AJ, Sewell AK, Burrows SR, Roederer M, Price DA, Wooldridge L, van den Berg HA. Szomolay B, et al. Among authors: ekeruche makinde j. Immunol Cell Biol. 2016 Jul;94(6):573-82. doi: 10.1038/icb.2016.12. Epub 2016 Feb 5. Immunol Cell Biol. 2016. PMID: 26846725 Free PMC article.
Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.
Clement M, Ladell K, Ekeruche-Makinde J, Miles JJ, Edwards ES, Dolton G, Williams T, Schauenburg AJ, Cole DK, Lauder SN, Gallimore AM, Godkin AJ, Burrows SR, Price DA, Sewell AK, Wooldridge L. Clement M, et al. Among authors: ekeruche makinde j. J Immunol. 2011 Jul 15;187(2):654-63. doi: 10.4049/jimmunol.1003941. Epub 2011 Jun 15. J Immunol. 2011. PMID: 21677135 Free PMC article.
A single autoimmune T cell receptor recognizes more than a million different peptides.
Wooldridge L, Ekeruche-Makinde J, van den Berg HA, Skowera A, Miles JJ, Tan MP, Dolton G, Clement M, Llewellyn-Lacey S, Price DA, Peakman M, Sewell AK. Wooldridge L, et al. Among authors: ekeruche makinde j. J Biol Chem. 2012 Jan 6;287(2):1168-77. doi: 10.1074/jbc.M111.289488. Epub 2011 Nov 18. J Biol Chem. 2012. PMID: 22102287 Free PMC article.
Peptide length determines the outcome of TCR/peptide-MHCI engagement.
Ekeruche-Makinde J, Miles JJ, van den Berg HA, Skowera A, Cole DK, Dolton G, Schauenburg AJ, Tan MP, Pentier JM, Llewellyn-Lacey S, Miles KM, Bulek AM, Clement M, Williams T, Trimby A, Bailey M, Rizkallah P, Rossjohn J, Peakman M, Price DA, Burrows SR, Sewell AK, Wooldridge L. Ekeruche-Makinde J, et al. Blood. 2013 Feb 14;121(7):1112-23. doi: 10.1182/blood-2012-06-437202. Epub 2012 Dec 18. Blood. 2013. PMID: 23255554 Free PMC article.
Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies.
Clement M, Pearson JA, Gras S, van den Berg HA, Lissina A, Llewellyn-Lacey S, Willis MD, Dockree T, McLaren JE, Ekeruche-Makinde J, Gostick E, Robertson NP, Rossjohn J, Burrows SR, Price DA, Wong FS, Peakman M, Skowera A, Wooldridge L. Clement M, et al. Among authors: ekeruche makinde j. Sci Rep. 2016 Oct 17;6:35332. doi: 10.1038/srep35332. Sci Rep. 2016. PMID: 27748447 Free PMC article.
Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
Cole DK, van den Berg HA, Lloyd A, Crowther MD, Beck K, Ekeruche-Makinde J, Miles JJ, Bulek AM, Dolton G, Schauenburg AJ, Wall A, Fuller A, Clement M, Laugel B, Rizkallah PJ, Wooldridge L, Sewell AK. Cole DK, et al. Among authors: ekeruche makinde j. J Biol Chem. 2017 Jan 20;292(3):802-813. doi: 10.1074/jbc.M116.741603. Epub 2016 Nov 30. J Biol Chem. 2017. PMID: 27903649 Free PMC article.
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.
Ekeruche-Makinde J, Clement M, Cole DK, Edwards ES, Ladell K, Miles JJ, Matthews KK, Fuller A, Lloyd KA, Madura F, Dolton GM, Pentier J, Lissina A, Gostick E, Baxter TK, Baker BM, Rizkallah PJ, Price DA, Wooldridge L, Sewell AK. Ekeruche-Makinde J, et al. J Biol Chem. 2012 Oct 26;287(44):37269-81. doi: 10.1074/jbc.M112.386409. Epub 2012 Sep 5. J Biol Chem. 2012. PMID: 22952231 Free PMC article.
Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization.
Mukhopadhya I, Murray GI, Berry S, Thomson J, Frank B, Gwozdz G, Ekeruche-Makinde J, Shattock R, Kelly C, Iannelli F, Pozzi G, El-Omar EM, Hold GL, Hijazi K. Mukhopadhya I, et al. Among authors: ekeruche makinde j. J Antimicrob Chemother. 2016 Feb;71(2):372-86. doi: 10.1093/jac/dkv335. Epub 2015 Oct 29. J Antimicrob Chemother. 2016. PMID: 26514157