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Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.
Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NY, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong WW, Silke J. Lalaoui N, et al. Among authors: gaestel m. Cancer Cell. 2016 Feb 8;29(2):145-58. doi: 10.1016/j.ccell.2016.01.006. Cancer Cell. 2016. PMID: 26859455 Free article.
Distinct cellular functions of MK2.
Kotlyarov A, Yannoni Y, Fritz S, Laass K, Telliez JB, Pitman D, Lin LL, Gaestel M. Kotlyarov A, et al. Among authors: gaestel m. Mol Cell Biol. 2002 Jul;22(13):4827-35. doi: 10.1128/MCB.22.13.4827-4835.2002. Mol Cell Biol. 2002. PMID: 12052889 Free PMC article.
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element.
Hitti E, Iakovleva T, Brook M, Deppenmeier S, Gruber AD, Radzioch D, Clark AR, Blackshear PJ, Kotlyarov A, Gaestel M. Hitti E, et al. Among authors: gaestel m. Mol Cell Biol. 2006 Mar;26(6):2399-407. doi: 10.1128/MCB.26.6.2399-2407.2006. Mol Cell Biol. 2006. PMID: 16508014 Free PMC article.
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.
Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB. Ronkina N, et al. Among authors: gaestel m. Mol Cell Biol. 2007 Jan;27(1):170-81. doi: 10.1128/MCB.01456-06. Epub 2006 Oct 9. Mol Cell Biol. 2007. PMID: 17030606 Free PMC article.
MK2 and MK3--a pair of isoenzymes?
Ronkina N, Kotlyarov A, Gaestel M. Ronkina N, et al. Among authors: gaestel m. Front Biosci. 2008 May 1;13:5511-21. doi: 10.2741/3095. Front Biosci. 2008. PMID: 18508601 Review.
271 results