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NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.
Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF. Ma C, et al. Among authors: heikenwalder m. Nature. 2016 Mar 10;531(7593):253-7. doi: 10.1038/nature16969. Epub 2016 Mar 2. Nature. 2016. PMID: 26934227 Free PMC article.
A lymphotoxin-driven pathway to hepatocellular carcinoma.
Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M. Haybaeck J, et al. Among authors: heikenwalder m. Cancer Cell. 2009 Oct 6;16(4):295-308. doi: 10.1016/j.ccr.2009.08.021. Cancer Cell. 2009. PMID: 19800575 Free PMC article.
COX-2 is not required for the development of murine chronic pancreatitis.
Silva A, Weber A, Bain M, Reding T, Heikenwalder M, Sonda S, Graf R. Silva A, et al. Among authors: heikenwalder m. Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G968-75. doi: 10.1152/ajpgi.00497.2010. Epub 2011 Mar 3. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21372163 Free article.
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L. Kang TW, et al. Among authors: heikenwalder m. Nature. 2011 Nov 9;479(7374):547-51. doi: 10.1038/nature10599. Nature. 2011. PMID: 22080947
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.
Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M, Knolle PA. Huang LR, et al. Among authors: heikenwalder m. Nat Immunol. 2013 Jun;14(6):574-83. doi: 10.1038/ni.2573. Epub 2013 Apr 14. Nat Immunol. 2013. PMID: 23584070
RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation.
Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Cardenas DV, Kreggenwinkel K, Koppe C, Hammerich L, Hakem R, Unger K, Weber A, Gassler N, Luedde M, Frey N, Neumann UP, Tacke F, Trautwein C, Heikenwalder M, Luedde T. Vucur M, et al. Among authors: heikenwalder m. Cell Rep. 2013 Aug 29;4(4):776-90. doi: 10.1016/j.celrep.2013.07.035. Epub 2013 Aug 22. Cell Rep. 2013. PMID: 23972991 Free article.
Intratumor heterogeneity in hepatocellular carcinoma.
Friemel J, Rechsteiner M, Frick L, Böhm F, Struckmann K, Egger M, Moch H, Heikenwalder M, Weber A. Friemel J, et al. Among authors: heikenwalder m. Clin Cancer Res. 2015 Apr 15;21(8):1951-61. doi: 10.1158/1078-0432.CCR-14-0122. Epub 2014 Sep 23. Clin Cancer Res. 2015. PMID: 25248380 Free article.
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.
Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V. Jeltsch KM, et al. Among authors: heikenwalder m. Nat Immunol. 2014 Nov;15(11):1079-89. doi: 10.1038/ni.3008. Epub 2014 Oct 5. Nat Immunol. 2014. PMID: 25282160
329 results