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The JAK/STAT pathway in obesity and diabetes.
Gurzov EN, Stanley WJ, Pappas EG, Thomas HE, Gough DJ. Gurzov EN, et al. Among authors: pappas eg. FEBS J. 2016 Aug;283(16):3002-15. doi: 10.1111/febs.13709. Epub 2016 Apr 1. FEBS J. 2016. PMID: 26972840 Free article. Review.
Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.
Mollah ZUA, Quah HS, Graham KL, Jhala G, Krishnamurthy B, Dharma JFM, Chee J, Trivedi PM, Pappas EG, Mackin L, Chu EPF, Akazawa S, Fynch S, Hodson C, Deans AJ, Trapani JA, Chong MMW, Bird PI, Brodnicki TC, Thomas HE, Kay TWH. Mollah ZUA, et al. Among authors: pappas eg. Diabetes. 2017 Dec;66(12):3041-3050. doi: 10.2337/db17-0517. Epub 2017 Jul 21. Diabetes. 2017. PMID: 28733313
Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice.
Wali JA, Galic S, Tan CY, Gurzov EN, Frazier AE, Connor T, Ge J, Pappas EG, Stroud D, Varanasi LC, Selck C, Ryan MT, Thorburn DR, Kemp BE, Krishnamurthy B, Kay TW, McGee SL, Thomas HE. Wali JA, et al. Among authors: pappas eg. Cell Death Differ. 2018 Jan;25(1):217-225. doi: 10.1038/cdd.2017.168. Epub 2017 Oct 20. Cell Death Differ. 2018. PMID: 29053141 Free PMC article.
Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.
Bensellam M, Shi YC, Chan JY, Laybutt DR, Chae H, Abou-Samra M, Pappas EG, Thomas HE, Gilon P, Jonas JC. Bensellam M, et al. Among authors: pappas eg. Diabetologia. 2019 Dec;62(12):2273-2286. doi: 10.1007/s00125-019-05008-3. Epub 2019 Oct 17. Diabetologia. 2019. PMID: 31624901
The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-γ and Common γ Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice.
Ge T, Jhala G, Fynch S, Akazawa S, Litwak S, Pappas EG, Catterall T, Vakil I, Long AJ, Olson LM, Krishnamurthy B, Kay TW, Thomas HE. Ge T, et al. Among authors: pappas eg. Front Immunol. 2020 Dec 4;11:588543. doi: 10.3389/fimmu.2020.588543. eCollection 2020. Front Immunol. 2020. PMID: 33343569 Free PMC article.
Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice.
Jhala G, Selck C, Chee J, Kwong CJ, Pappas EG, Thomas HE, Kay TWH, Krishnamurthy B. Jhala G, et al. Among authors: pappas eg. Front Immunol. 2021 Mar 25;12:645817. doi: 10.3389/fimmu.2021.645817. eCollection 2021. Front Immunol. 2021. PMID: 33841427 Free PMC article.
Severe acute respiratory syndrome coronavirus 2 as a potential cause of type 1 diabetes facilitated by spike protein receptor binding domain attachment to human islet cells: An illustrative case study and experimental data.
Venkatesh N, Astbury N, Thomas MC, Rosado CJ, Pappas E, Krishnamurthy B, MacIsaac RJ, Kay TWH, Thomas HE, O'Neal DN. Venkatesh N, et al. Diabet Med. 2021 Nov;38(11):e14608. doi: 10.1111/dme.14608. Epub 2021 Jun 10. Diabet Med. 2021. PMID: 34043837 Free PMC article.
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