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Human mast cells capture, store, and release bioactive, exogenous IL-17A.
Noordenbos T, Blijdorp I, Chen S, Stap J, Mul E, Cañete JD, Lubberts E, Yeremenko N, Baeten D. Noordenbos T, et al. Among authors: lubberts e. J Leukoc Biol. 2016 Sep;100(3):453-62. doi: 10.1189/jlb.3HI1215-542R. Epub 2016 Mar 31. J Leukoc Biol. 2016. PMID: 27034403
Accelerated menopausal changes as human disease model 'FOCUM' for the development of osteoarthritis and other degenerative disorders: protocol for a prospective cohort study.
Molendijk E, Schiphof D, Oei EHG, de Vos RJ, Bos PK, van Meurs JBJ, Lubberts E, Zillikens MC, van der Eerden BCJ, Kavousi M, Schouten BWV, de Rooij-Duran MIB, Bierma-Zeinstra SMA. Molendijk E, et al. Among authors: lubberts e. BMJ Open. 2022 Nov 14;12(11):e064779. doi: 10.1136/bmjopen-2022-064779. BMJ Open. 2022. PMID: 36375984 Free PMC article.
Interleukin-17A Is Produced by CD4+ but Not CD8+ T Cells in Synovial Fluid Following T Cell Receptor Activation and Regulates Different Inflammatory Mediators Compared to Tumor Necrosis Factor in a Model of Psoriatic Arthritis Synovitis.
Xu X, Davelaar N, Mus AM, Asmawidjaja PS, Hazes JMW, Baeten DLP, Vis M, Bisoendial RJ, Prens EP, Lubberts E. Xu X, et al. Among authors: lubberts e. Arthritis Rheumatol. 2020 Aug;72(8):1303-1313. doi: 10.1002/art.41271. Epub 2020 Jul 8. Arthritis Rheumatol. 2020. PMID: 32243724 Free PMC article.
IL-17 produced by Paneth cells drives TNF-induced shock.
Takahashi N, Vanlaere I, de Rycke R, Cauwels A, Joosten LA, Lubberts E, van den Berg WB, Libert C. Takahashi N, et al. Among authors: lubberts e. J Exp Med. 2008 Aug 4;205(8):1755-61. doi: 10.1084/jem.20080588. Epub 2008 Jul 28. J Exp Med. 2008. PMID: 18663129 Free PMC article.
Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production.
van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Colin EM, Hazes JM, Dolhain RJ, Lubberts E. van Hamburg JP, et al. Among authors: lubberts e. Arthritis Rheum. 2011 Jan;63(1):73-83. doi: 10.1002/art.30093. Arthritis Rheum. 2011. PMID: 20954258 Free article.
TNF blockade requires 1,25(OH)2D3 to control human Th17-mediated synovial inflammation.
van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Cornelissen F, van Leeuwen JP, Hazes JM, Dolhain RJ, Bakx PA, Colin EM, Lubberts E. van Hamburg JP, et al. Among authors: lubberts e. Ann Rheum Dis. 2012 Apr;71(4):606-12. doi: 10.1136/annrheumdis-2011-200424. Epub 2012 Jan 4. Ann Rheum Dis. 2012. PMID: 22219138
IL-17/Th17 mediated synovial inflammation is IL-22 independent.
van Hamburg JP, Corneth OB, Paulissen SM, Davelaar N, Asmawidjaja PS, Mus AM, Lubberts E. van Hamburg JP, et al. Among authors: lubberts e. Ann Rheum Dis. 2013 Oct;72(10):1700-7. doi: 10.1136/annrheumdis-2012-202373. Epub 2013 Jan 17. Ann Rheum Dis. 2013. PMID: 23328939
126 results