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Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function.
Piol D, Tosatto L, Zuccaro E, Anderson EN, Falconieri A, Polanco MJ, Marchioretti C, Lia F, White J, Bregolin E, Minervini G, Parodi S, Salvatella X, Arrigoni G, Ballabio A, La Spada AR, Tosatto SCE, Sambataro F, Medina DL, Pandey UB, Basso M, Pennuto M. Piol D, et al. Among authors: salvatella x. Sci Adv. 2023 Jan 6;9(1):eade1694. doi: 10.1126/sciadv.ade1694. Epub 2023 Jan 6. Sci Adv. 2023. PMID: 36608116 Free PMC article.
Correlated motions are a fundamental property of β-sheets.
Fenwick RB, Orellana L, Esteban-Martín S, Orozco M, Salvatella X. Fenwick RB, et al. Among authors: salvatella x. Nat Commun. 2014 Jun 11;5:4070. doi: 10.1038/ncomms5070. Nat Commun. 2014. PMID: 24915882 Free article.
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor.
Escobedo A, Topal B, Kunze MBA, Aranda J, Chiesa G, Mungianu D, Bernardo-Seisdedos G, Eftekharzadeh B, Gairí M, Pierattelli R, Felli IC, Diercks T, Millet O, García J, Orozco M, Crehuet R, Lindorff-Larsen K, Salvatella X. Escobedo A, et al. Among authors: salvatella x. Nat Commun. 2019 May 2;10(1):2034. doi: 10.1038/s41467-019-09923-2. Nat Commun. 2019. PMID: 31048691 Free PMC article.
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.
Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pierattelli R, Felli IC, Brun-Heath I, García J, Nebreda ÁR, Gestwicki JE, Lieberman AP, Salvatella X. Eftekharzadeh B, et al. Among authors: salvatella x. Nat Commun. 2019 Aug 8;10(1):3562. doi: 10.1038/s41467-019-11594-y. Nat Commun. 2019. PMID: 31395886 Free PMC article.
Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.
Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pierattelli R, Felli IC, Brun-Heath I, García J, Nebreda ÁR, Gestwicki JE, Lieberman AP, Salvatella X. Eftekharzadeh B, et al. Among authors: salvatella x. Nat Commun. 2019 Oct 7;10(1):4605. doi: 10.1038/s41467-019-12578-8. Nat Commun. 2019. PMID: 31591399 Free PMC article.
A glutamine-based single α-helix scaffold to target globular proteins.
Escobedo A, Piccirillo J, Aranda J, Diercks T, Mateos B, Garcia-Cabau C, Sánchez-Navarro M, Topal B, Biesaga M, Staby L, Kragelund BB, García J, Millet O, Orozco M, Coles M, Crehuet R, Salvatella X. Escobedo A, et al. Among authors: salvatella x. Nat Commun. 2022 Nov 18;13(1):7073. doi: 10.1038/s41467-022-34793-6. Nat Commun. 2022. PMID: 36400768 Free PMC article.
87 results