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Programming inactive RNA-binding small molecules into bioactive degraders.
Tong Y, Lee Y, Liu X, Childs-Disney JL, Suresh BM, Benhamou RI, Yang C, Li W, Costales MG, Haniff HS, Sievers S, Abegg D, Wegner T, Paulisch TO, Lekah E, Grefe M, Crynen G, Van Meter M, Wang T, Gibaut QMR, Cleveland JL, Adibekian A, Glorius F, Waldmann H, Disney MD. Tong Y, et al. Among authors: costales mg. Nature. 2023 Jun;618(7963):169-179. doi: 10.1038/s41586-023-06091-8. Epub 2023 May 24. Nature. 2023. PMID: 37225982 Free PMC article.
CANVAS: A New Genetic Entity in the Otorhinolaryngologist's Differential Diagnosis.
Costales M, Casanueva R, Suárez V, Asensi JM, Cifuentes GA, Diñeiro M, Cadiñanos J, López F, Álvarez-Marcos C, Otero A, Gómez J, Llorente JL, Cabanillas R. Costales M, et al. Otolaryngol Head Neck Surg. 2022 Jan;166(1):74-79. doi: 10.1177/01945998211008398. Epub 2021 May 4. Otolaryngol Head Neck Surg. 2022. PMID: 33940977
Radixin modulates the function of outer hair cell stereocilia.
Prasad S, Vona B, Diñeiro M, Costales M, González-Aguado R, Fontalba A, Diego-Pérez C, Subasioglu A, Bademci G, Tekin M, Cabanillas R, Cadiñanos J, Fridberger A. Prasad S, et al. Among authors: costales m. Commun Biol. 2020 Dec 23;3(1):792. doi: 10.1038/s42003-020-01506-y. Commun Biol. 2020. PMID: 33361775 Free PMC article.
How We Think about Targeting RNA with Small Molecules.
Costales MG, Childs-Disney JL, Haniff HS, Disney MD. Costales MG, et al. J Med Chem. 2020 Sep 10;63(17):8880-8900. doi: 10.1021/acs.jmedchem.9b01927. Epub 2020 Mar 26. J Med Chem. 2020. PMID: 32212706 Free PMC article.
Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer.
Costales MG, Aikawa H, Li Y, Childs-Disney JL, Abegg D, Hoch DG, Pradeep Velagapudi S, Nakai Y, Khan T, Wang KW, Yildirim I, Adibekian A, Wang ET, Disney MD. Costales MG, et al. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2406-2411. doi: 10.1073/pnas.1914286117. Epub 2020 Jan 21. Proc Natl Acad Sci U S A. 2020. PMID: 31964809 Free PMC article.
72 results