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Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.
Severson TM, Nevedomskaya E, Peeters J, Kuilman T, Krijgsman O, van Rossum A, Droog M, Kim Y, Koornstra R, Beumer I, Glas AM, Peeper D, Wesseling J, Simon IM, Wessels L, Linn SC, Zwart W. Severson TM, et al. Among authors: droog m. Oncotarget. 2016 Jun 7;7(23):33901-18. doi: 10.18632/oncotarget.8983. Oncotarget. 2016. PMID: 27129152 Free PMC article. Clinical Trial.
Tamoxifen resistance: from bench to bedside.
Droog M, Beelen K, Linn S, Zwart W. Droog M, et al. Eur J Pharmacol. 2013 Oct 5;717(1-3):47-57. doi: 10.1016/j.ejphar.2012.11.071. Epub 2013 Mar 29. Eur J Pharmacol. 2013. PMID: 23545365 Review.
Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas.
Droog M, Nevedomskaya E, Kim Y, Severson T, Flach KD, Opdam M, Schuurman K, Gradowska P, Hauptmann M, Dackus G, Hollema H, Mourits M, Nederlof P, van Boven H, Linn SC, Wessels L, van Leeuwen FE, Zwart W. Droog M, et al. Cancer Res. 2016 Jul 1;76(13):3773-84. doi: 10.1158/0008-5472.CAN-14-1813. Epub 2016 May 6. Cancer Res. 2016. PMID: 27197147
SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer.
Zwart W, Flach KD, Rudraraju B, Abdel-Fatah TM, Gojis O, Canisius S, Moore D, Nevedomskaya E, Opdam M, Droog M, Hofland I, Chan S, Shaw J, Ellis IO, Coombes RC, Carroll JS, Ali S, Palmieri C. Zwart W, et al. Among authors: droog m. Clin Cancer Res. 2016 Jan 15;22(2):479-91. doi: 10.1158/1078-0432.CCR-14-3277. Epub 2015 Sep 14. Clin Cancer Res. 2016. PMID: 26369632
The Estrogen Receptor α-Cistrome Beyond Breast Cancer.
Droog M, Mensink M, Zwart W. Droog M, et al. Mol Endocrinol. 2016 Oct;30(10):1046-1058. doi: 10.1210/me.2016-1062. Epub 2016 Aug 4. Mol Endocrinol. 2016. PMID: 27489947 Free PMC article. Review.
FOXA1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome.
Schrijver W, Schuurman K, van Rossum A, Droog M, Jeronimo C, Salta S, Henrique R, Wesseling J, Moelans C, Linn SC, van den Heuvel M, van Diest P, Zwart W. Schrijver W, et al. Among authors: droog m. Mol Oncol. 2018 Nov;12(11):1884-1894. doi: 10.1002/1878-0261.12353. Epub 2018 Oct 12. Mol Oncol. 2018. PMID: 29972720 Free PMC article. Clinical Trial.
Optimized ChIP-seq method facilitates transcription factor profiling in human tumors.
Singh AA, Schuurman K, Nevedomskaya E, Stelloo S, Linder S, Droog M, Kim Y, Sanders J, van der Poel H, Bergman AM, Wessels LF, Zwart W. Singh AA, et al. Among authors: droog m. Life Sci Alliance. 2018 Dec 28;2(1):e201800115. doi: 10.26508/lsa.201800115. eCollection 2019 Feb. Life Sci Alliance. 2018. PMID: 30620009 Free PMC article.
Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer.
Rudraraju B, Droog M, Abdel-Fatah TM, Zwart W, Giannoudis A, Malki MI, Moore D, Patel H, Shaw J, Ellis IO, Chan S, Brooke GN, Nevedomskaya E, Lo Nigro C, Carroll J, Coombes RC, Bevan C, Ali S, Palmieri C. Rudraraju B, et al. Among authors: droog m. Breast Cancer Res Treat. 2014 Sep;147(2):295-309. doi: 10.1007/s10549-014-3098-0. Epub 2014 Aug 22. Breast Cancer Res Treat. 2014. PMID: 25141981
13 results