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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.
Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J. Brumatti G, et al. Among authors: johnstone rw. Sci Transl Med. 2016 May 18;8(339):339ra69. doi: 10.1126/scitranslmed.aad3099. Sci Transl Med. 2016. PMID: 27194727
Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.
Sedelies KA, Ciccone A, Clarke CJ, Oliaro J, Sutton VR, Scott FL, Silke J, Susanto O, Green DR, Johnstone RW, Bird PI, Trapani JA, Waterhouse NJ. Sedelies KA, et al. Among authors: johnstone rw. Cell Death Differ. 2008 Apr;15(4):708-17. doi: 10.1038/sj.cdd.4402300. Epub 2008 Jan 18. Cell Death Differ. 2008. PMID: 18202705
Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.
Waibel M, Solomon VS, Knight DA, Ralli RA, Kim SK, Banks KM, Vidacs E, Virely C, Sia KC, Bracken LS, Collins-Underwood R, Drenberg C, Ramsey LB, Meyer SC, Takiguchi M, Dickins RA, Levine R, Ghysdael J, Dawson MA, Lock RB, Mullighan CG, Johnstone RW. Waibel M, et al. Among authors: johnstone rw. Cell Rep. 2013 Nov 27;5(4):1047-59. doi: 10.1016/j.celrep.2013.10.038. Epub 2013 Nov 21. Cell Rep. 2013. PMID: 24268771 Free PMC article.
Id2 represses E2A-mediated activation of IL-10 expression in T cells.
Masson F, Ghisi M, Groom JR, Kallies A, Seillet C, Johnstone RW, Nutt SL, Belz GT. Masson F, et al. Among authors: johnstone rw. Blood. 2014 May 29;123(22):3420-8. doi: 10.1182/blood-2014-03-561456. Epub 2014 Apr 10. Blood. 2014. PMID: 24723679 Free article.
Autophagy and AML--food for thought.
Lalaoui N, Johnstone R, Ekert PG. Lalaoui N, et al. Cell Death Differ. 2016 Jan;23(1):5-6. doi: 10.1038/cdd.2015.136. Epub 2015 Oct 30. Cell Death Differ. 2016. PMID: 26517530 Free PMC article. No abstract available.
286 results