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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.
Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J. Brumatti G, et al. Among authors: silke n, silke j. Sci Transl Med. 2016 May 18;8(339):339ra69. doi: 10.1126/scitranslmed.aad3099. Sci Transl Med. 2016. PMID: 27194727
Cell death: shadow baxing.
Silke J, Vaux DL. Silke J, et al. Curr Biol. 1998 Jul 16;8(15):R528-31. doi: 10.1016/s0960-9822(07)00339-9. Curr Biol. 1998. PMID: 9705928 Free article. Review.
Caspase inhibitors.
Ekert PG, Silke J, Vaux DL. Ekert PG, et al. Among authors: silke j. Cell Death Differ. 1999 Nov;6(11):1081-6. doi: 10.1038/sj.cdd.4400594. Cell Death Differ. 1999. PMID: 10578177 Review.
Till death do us part.
Ekert PG, Silke J. Ekert PG, et al. Among authors: silke j. Cell Death Differ. 2001 Jul;8(7):662-4. doi: 10.1038/sj.cdd.4400895. Cell Death Differ. 2001. PMID: 11464210 No abstract available.
246 results