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A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.
Nevens F, Andreone P, Mazzella G, Strasser SI, Bowlus C, Invernizzi P, Drenth JP, Pockros PJ, Regula J, Beuers U, Trauner M, Jones DE, Floreani A, Hohenester S, Luketic V, Shiffman M, van Erpecum KJ, Vargas V, Vincent C, Hirschfield GM, Shah H, Hansen B, Lindor KD, Marschall HU, Kowdley KV, Hooshmand-Rad R, Marmon T, Sheeron S, Pencek R, MacConell L, Pruzanski M, Shapiro D; POISE Study Group. Nevens F, et al. Among authors: van erpecum kj. N Engl J Med. 2016 Aug 18;375(7):631-43. doi: 10.1056/NEJMoa1509840. N Engl J Med. 2016. PMID: 27532829 Free article. Clinical Trial.
Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid.
Kuiper EM, Hansen BE, de Vries RA, den Ouden-Muller JW, van Ditzhuijsen TJ, Haagsma EB, Houben MH, Witteman BJ, van Erpecum KJ, van Buuren HR; Dutch PBC Study Group. Kuiper EM, et al. Among authors: van buuren hr, van erpecum kj, van ditzhuijsen tj. Gastroenterology. 2009 Apr;136(4):1281-7. doi: 10.1053/j.gastro.2009.01.003. Epub 2009 Jan 14. Gastroenterology. 2009. PMID: 19208346
No beneficial effects of amantadine in treatment of chronic hepatitis C patients.
van Soest H, van der Schaar PJ, Koek GH, de Vries RA, van Ooteghem NA, van Hoek B, Drenth JP, Vrolijk JM, Lieverse RJ, Houben P, van der Sluys Veer A, Siersema PD, Schipper ME, van Erpecum KJ, Boland GJ. van Soest H, et al. Among authors: van hoek b, van erpecum kj, van der schaar pj, van der sluys veer a, van ooteghem na. Dig Liver Dis. 2010 Jul;42(7):496-502. doi: 10.1016/j.dld.2009.10.006. Epub 2009 Dec 16. Dig Liver Dis. 2010. PMID: 20018575 Clinical Trial.
Lysophosphatidic acid is a potential mediator of cholestatic pruritus.
Kremer AE, Martens JJ, Kulik W, Ruëff F, Kuiper EM, van Buuren HR, van Erpecum KJ, Kondrackiene J, Prieto J, Rust C, Geenes VL, Williamson C, Moolenaar WH, Beuers U, Oude Elferink RP. Kremer AE, et al. Among authors: van buuren hr, van erpecum kj. Gastroenterology. 2010 Sep;139(3):1008-18, 1018.e1. doi: 10.1053/j.gastro.2010.05.009. Epub 2010 Jun 19. Gastroenterology. 2010. PMID: 20546739
Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions.
Kremer AE, van Dijk R, Leckie P, Schaap FG, Kuiper EM, Mettang T, Reiners KS, Raap U, van Buuren HR, van Erpecum KJ, Davies NA, Rust C, Engert A, Jalan R, Oude Elferink RP, Beuers U. Kremer AE, et al. Among authors: van buuren hr, van erpecum kj, van dijk r. Hepatology. 2012 Oct;56(4):1391-400. doi: 10.1002/hep.25748. Hepatology. 2012. PMID: 22473838
Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission.
van Gerven NM, Verwer BJ, Witte BI, van Hoek B, Coenraad MJ, van Erpecum KJ, Beuers U, van Buuren HR, de Man RA, Drenth JP, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MM, Mulder CJ, van Nieuwkerk KM, Bouma G; Dutch Autoimmune Hepatitis Working Group. van Gerven NM, et al. Among authors: van buuren hr, van nieuwkerk km, van hoek b, van erpecum kj. J Hepatol. 2013 Jan;58(1):141-7. doi: 10.1016/j.jhep.2012.09.009. Epub 2012 Sep 16. J Hepatol. 2013. PMID: 22989569
Cytotoxic T lymphocyte antigen-4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis.
van Gerven NM, de Boer YS, Zwiers A, van Hoek B, van Erpecum KJ, Beuers U, van Buuren HR, Drenth JP, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MM, Vrolijk JM, Kraal G, Mulder CJ, van Nieuwkerk CM, Bouma G; Dutch Autoimmune Hepatitis Study group. van Gerven NM, et al. Among authors: van buuren hr, van hoek b, van erpecum kj, van nieuwkerk cm. Liver Int. 2013 Aug;33(7):1039-43. doi: 10.1111/liv.12157. Epub 2013 Mar 31. Liver Int. 2013. PMID: 23551963
273 results