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Endothelial Cell Insulin Signaling Regulates CXCR4 (C-X-C Motif Chemokine Receptor 4) and Limits Leukocyte Adhesion to Endothelium.
Rathjen T, Kunkemoeller B, Cederquist CT, Wang X, Lockhart SM, Patti JC, Willenbrock H, Olsen GS, Povlsen GK, Beck HC, Rasmussen LM, Li Q, Park K, King GL, Rask-Madsen C. Rathjen T, et al. Among authors: lockhart sm. Arterioscler Thromb Vasc Biol. 2022 Jul;42(7):e217-e227. doi: 10.1161/ATVBAHA.122.317476. Epub 2022 Jun 2. Arterioscler Thromb Vasc Biol. 2022. PMID: 35652755 Free PMC article.
The excess insulin requirement in severe COVID-19 compared to non-COVID-19 viral pneumonitis is related to the severity of respiratory failure and pre-existing diabetes.
Lockhart SM, Griffiths H, Petrisor B, Usman A, Calvo-Latorre J, Heales L, Bansiya V, Mahroof R, Conway Morris A. Lockhart SM, et al. Endocrinol Diabetes Metab. 2021 Feb 11;4(3):e00228. doi: 10.1002/edm2.228. eCollection 2021 Jul. Endocrinol Diabetes Metab. 2021. PMID: 34268452 Free PMC article.
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.
Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman IE, Amenta PS, Feener EP, Vander Heiden MG, Stanton RC, King GL. Qi W, et al. Nat Med. 2017 Jun;23(6):753-762. doi: 10.1038/nm.4328. Epub 2017 Apr 24. Nat Med. 2017. PMID: 28436957 Free PMC article.
Circulating adipokines are associated with pre-eclampsia in women with type 1 diabetes.
Kelly CB, Hookham MB, Yu JY, Lockhart SM, Du M, Jenkins AJ, Nankervis A, Hanssen KF, Henriksen T, Garg SK, Hammad SM, Scardo JA, Aston CE, Patterson CC, Lyons TJ. Kelly CB, et al. Among authors: lockhart sm. Diabetologia. 2017 Dec;60(12):2514-2524. doi: 10.1007/s00125-017-4415-z. Epub 2017 Sep 5. Diabetologia. 2017. PMID: 28875223 Free PMC article.
Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.
Cimino I, Kim H, Tung YCL, Pedersen K, Rimmington D, Tadross JA, Kohnke SN, Neves-Costa A, Barros A, Joaquim S, Bennett D, Melvin A, Lockhart SM, Rostron AJ, Scott J, Liu H, Burling K, Barker P, Clatworthy MR, Lee EC, Simpson AJ, Yeo GSH, Moita LF, Bence KK, Jørgensen SB, Coll AP, Breen DM, O'Rahilly S. Cimino I, et al. Among authors: lockhart sm. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2106868118. doi: 10.1073/pnas.2106868118. Proc Natl Acad Sci U S A. 2021. PMID: 34187898 Free PMC article.
42 results