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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.
Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, da Costa AS, Gaude E, Drubbel AV, Theobald SJ, Abbo SR, Tran MG, Rajeeve V, Cardaci S, Foster S, Yun H, Cutillas P, Warren A, Gnanapragasam V, Gottlieb E, Franze K, Huntly B, Maher ER, Maxwell PH, Saez-Rodriguez J, Frezza C. Sciacovelli M, et al. Among authors: gottlieb e. Nature. 2016 Aug 31;537(7621):544-547. doi: 10.1038/nature19353. Nature. 2016. PMID: 27580029 Free PMC article.
Mitochondria in cancer: not just innocent bystanders.
Frezza C, Gottlieb E. Frezza C, et al. Among authors: gottlieb e. Semin Cancer Biol. 2009 Feb;19(1):4-11. doi: 10.1016/j.semcancer.2008.11.008. Epub 2008 Dec 3. Semin Cancer Biol. 2009. PMID: 19101633 Review.
IDH1 mutations in gliomas: when an enzyme loses its grip.
Frezza C, Tennant DA, Gottlieb E. Frezza C, et al. Among authors: gottlieb e. Cancer Cell. 2010 Jan 19;17(1):7-9. doi: 10.1016/j.ccr.2009.12.031. Cancer Cell. 2010. PMID: 20129244 Free article.
Inborn and acquired metabolic defects in cancer.
Frezza C, Pollard PJ, Gottlieb E. Frezza C, et al. Among authors: gottlieb e. J Mol Med (Berl). 2011 Mar;89(3):213-20. doi: 10.1007/s00109-011-0728-4. Epub 2011 Feb 8. J Mol Med (Berl). 2011. PMID: 21301796 Free PMC article. Review.
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Frezza C, Zheng L, Folger O, Rajagopalan KN, MacKenzie ED, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson IP, Pollard PJ, Watson DG, Deberardinis RJ, Shlomi T, Ruppin E, Gottlieb E. Frezza C, et al. Among authors: gottlieb e. Nature. 2011 Aug 17;477(7363):225-8. doi: 10.1038/nature10363. Nature. 2011. PMID: 21849978
438 results