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Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.
Zambetti NA, Ping Z, Chen S, Kenswil KJG, Mylona MA, Sanders MA, Hoogenboezem RM, Bindels EMJ, Adisty MN, Van Strien PMH, van der Leije CS, Westers TM, Cremers EMP, Milanese C, Mastroberardino PG, van Leeuwen JPTM, van der Eerden BCJ, Touw IP, Kuijpers TW, Kanaar R, van de Loosdrecht AA, Vogl T, Raaijmakers MHGP. Zambetti NA, et al. Among authors: chen s. Cell Stem Cell. 2016 Nov 3;19(5):613-627. doi: 10.1016/j.stem.2016.08.021. Epub 2016 Sep 22. Cell Stem Cell. 2016. PMID: 27666011 Free article.
Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes.
Ping Z, Chen S, Hermans SJF, Kenswil KJG, Feyen J, van Dijk C, Bindels EMJ, Mylona AM, Adisty NM, Hoogenboezem RM, Sanders MA, Cremers EMP, Lindenbergh-Kortleve DJ, Samsom JN, van de Loosdrecht AA, Raaijmakers MHGP. Ping Z, et al. Among authors: chen s. Leukemia. 2019 Feb;33(2):536-541. doi: 10.1038/s41375-018-0267-x. Epub 2018 Oct 12. Leukemia. 2019. PMID: 30315231 Free PMC article.
Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs.
Chen S, Zambetti NA, Bindels EM, Kenswill K, Mylona AM, Adisty NM, Hoogenboezem RM, Sanders MA, Cremers EM, Westers TM, Jansen JH, van de Loosdrecht AA, Raaijmakers MH. Chen S, et al. Leukemia. 2016 Sep;30(9):1938-42. doi: 10.1038/leu.2016.91. Epub 2016 Apr 25. Leukemia. 2016. PMID: 27109510 Free PMC article. No abstract available.
Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation.
Bhagat TD, Chen S, Bartenstein M, Barlowe AT, Von Ahrens D, Choudhary GS, Tivnan P, Amin E, Marcondes AM, Sanders MA, Hoogenboezem RM, Kambhampati S, Ramachandra N, Mantzaris I, Sukrithan V, Laurence R, Lopez R, Bhagat P, Giricz O, Sohal D, Wickrema A, Yeung C, Gritsman K, Aplan P, Hochedlinger K, Yu Y, Pradhan K, Zhang J, Greally JM, Mukherjee S, Pellagatti A, Boultwood J, Will B, Steidl U, Raaijmakers MHGP, Deeg HJ, Kharas MG, Verma A. Bhagat TD, et al. Among authors: chen s. Cancer Res. 2017 Sep 15;77(18):4846-4857. doi: 10.1158/0008-5472.CAN-17-0282. Epub 2017 Jul 6. Cancer Res. 2017. PMID: 28684528 Free PMC article.
Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome.
Ribezzo F, Snoeren IAM, Ziegler S, Stoelben J, Olofsen PA, Henic A, Ferreira MV, Chen S, Stalmann USA, Buesche G, Hoogenboezem RM, Kramann R, Platzbecker U, Raaijmakers MHGP, Ebert BL, Schneider RK. Ribezzo F, et al. Among authors: chen s. Leukemia. 2019 Jul;33(7):1759-1772. doi: 10.1038/s41375-018-0350-3. Epub 2019 Jan 16. Leukemia. 2019. PMID: 30651631
Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.
Martín-Pardillos A, Tsaalbi-Shtylik A, Chen S, Lazare S, van Os RP, Dethmers-Ausema A, Fakouri NB, Bosshard M, Aprigliano R, van Loon B, Salvatori DCF, Hashimoto K, Dingemanse-van der Spek C, Moriya M, Rasmussen LJ, de Haan G, Raaijmakers MHGP, de Wind N. Martín-Pardillos A, et al. Among authors: chen s. Blood. 2017 Sep 28;130(13):1523-1534. doi: 10.1182/blood-2017-01-764274. Epub 2017 Aug 21. Blood. 2017. PMID: 28827409 Free PMC article.
Mutations in wheat TaAPA2 gene result in pleiotropic effects on plant architecture.
Bai S, Wang G, Song R, Liu Y, Hua L, Yang J, Zhang L, Ur Rehman S, Hao X, Hou L, Zhang C, Li H, Liang Y, Zhao L, Xue Y, Wang Z, Chen S. Bai S, et al. Among authors: chen s. Sci China Life Sci. 2024 Jun 3. doi: 10.1007/s11427-024-2620-7. Online ahead of print. Sci China Life Sci. 2024. PMID: 38842650 No abstract available.
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