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CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.
Dockree T, Holland CJ, Clement M, Ladell K, McLaren JE, van den Berg HA, Gostick E, L Miners K, Llewellyn-Lacey S, Bridgeman JS, Man S, Bailey M, Burrows SR, Price DA, Wooldridge L. Dockree T, et al. Among authors: bridgeman js. Immunol Cell Biol. 2017 Jan;95(1):68-76. doi: 10.1038/icb.2016.85. Epub 2016 Nov 8. Immunol Cell Biol. 2017. PMID: 27670790 Free PMC article.
Cellular-level versus receptor-level response threshold hierarchies in T-cell activation.
van den Berg HA, Ladell K, Miners K, Laugel B, Llewellyn-Lacey S, Clement M, Cole DK, Gostick E, Wooldridge L, Sewell AK, Bridgeman JS, Price DA. van den Berg HA, et al. Among authors: bridgeman js. Front Immunol. 2013 Sep 5;4:250. doi: 10.3389/fimmu.2013.00250. eCollection 2013. Front Immunol. 2013. PMID: 24046768 Free PMC article.
CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor.
Clement M, Knezevic L, Dockree T, McLaren JE, Ladell K, Miners KL, Llewellyn-Lacey S, Rubina A, Francis O, Cole DK, Sewell AK, Bridgeman JS, Price DA, van den Berg HA, Wooldridge L. Clement M, et al. Among authors: bridgeman js. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2019639118. doi: 10.1073/pnas.2019639118. Proc Natl Acad Sci U S A. 2021. PMID: 34272276 Free PMC article.
A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells.
Ladell K, Hashimoto M, Iglesias MC, Wilmann PG, McLaren JE, Gras S, Chikata T, Kuse N, Fastenackels S, Gostick E, Bridgeman JS, Venturi V, Arkoub ZA, Agut H, van Bockel DJ, Almeida JR, Douek DC, Meyer L, Venet A, Takiguchi M, Rossjohn J, Price DA, Appay V. Ladell K, et al. Among authors: bridgeman js. Immunity. 2013 Mar 21;38(3):425-36. doi: 10.1016/j.immuni.2012.11.021. Immunity. 2013. PMID: 23521884 Free article.
Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells.
Chen HC, Joalland N, Bridgeman JS, Alchami FS, Jarry U, Khan MWA, Piggott L, Shanneik Y, Li J, Herold MJ, Herrmann T, Price DA, Gallimore AM, Clarkson RW, Scotet E, Moser B, Eberl M. Chen HC, et al. Among authors: bridgeman js. Immunol Cell Biol. 2017 Aug;95(7):620-629. doi: 10.1038/icb.2017.21. Epub 2017 Mar 30. Immunol Cell Biol. 2017. PMID: 28356569 Free PMC article.
Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity.
O'Connor GM, Vivian JP, Widjaja JM, Bridgeman JS, Gostick E, Lafont BA, Anderson SK, Price DA, Brooks AG, Rossjohn J, McVicar DW. O'Connor GM, et al. Among authors: bridgeman js. J Immunol. 2014 Mar 15;192(6):2875-84. doi: 10.4049/jimmunol.1303142. Epub 2014 Feb 21. J Immunol. 2014. PMID: 24563253 Free PMC article.
51 results