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CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.
Dockree T, Holland CJ, Clement M, Ladell K, McLaren JE, van den Berg HA, Gostick E, L Miners K, Llewellyn-Lacey S, Bridgeman JS, Man S, Bailey M, Burrows SR, Price DA, Wooldridge L. Dockree T, et al. Among authors: l miners k, wooldridge l. Immunol Cell Biol. 2017 Jan;95(1):68-76. doi: 10.1038/icb.2016.85. Epub 2016 Nov 8. Immunol Cell Biol. 2017. PMID: 27670790 Free PMC article.
Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface.
Wooldridge L, Hutchinson SL, Choi EM, Lissina A, Jones E, Mirza F, Dunbar PR, Price DA, Cerundolo V, Sewell AK. Wooldridge L, et al. J Immunol. 2003 Dec 15;171(12):6650-60. doi: 10.4049/jimmunol.171.12.6650. J Immunol. 2003. PMID: 14662868
111 results